PMID- 29567278
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20181001
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 219
DP  - 2018 Jun 12
TI  - Antinociceptive activity of Inula britannica L. and patuletin: In vivo and 
      possible mechanisms studies.
PG  - 351-358
LID - S0378-8741(17)33902-8 [pii]
LID - 10.1016/j.jep.2018.03.021 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Inula britannica L. is a predominant medicinal 
      plant traditionally utilized in the treatments of arthritis and back pain in 
      Iranian folk medicine. AIM OF THE STUDY: The purpose of this research was to 
      evaluate the antinociceptive effects of Inula britannica L. flower essential oil 
      (IBLEO) and one of its major constituents, Patuletin (Pn), in male mice. 
      MATERIALS AND METHODS: In this study, we used pain assessment tests including 
      acetic acid-induced writhing, tail-flick (TF), formalin induced paw licking 
      (FIPL) model, and glutamate-induced paw licking (GPL). For understanding the 
      supposed antinociceptive mechanisms of IBLEO, opioid and L-arginine/NO/cGMP/ KATP 
      pathways were examined. RESULTS: In the TF, writhing, GPL, and FIPL tests, a 
      dosage of 100 mg/kg of IBLEO showed noteworthy antinociceptive effects in 
      comparison with control (p < 0.05). In writhing test, administration of selective 
      opioid antagonists (naltrindole, nor-binaltorphimine, and naloxonazine) 
      attenuated the antinociceptive effect of IBLEO in comparison with control 
      (p < 0.001). Both methylene blue and glibenclamide blocked the antinociceptive 
      effect of IBLEO (p < 0.05), but the administration of L-arginine or sodium 
      nitroprusside fundamentally potentiated the antinociception induced by IBLEO in 
      phase II of the FIPL (p < 0.05). Additionally, patuletin showed significant 
      antinociceptive effects in writhing, FIPL, and GPL tests (p < 0.01). CONCLUSION: 
      The results of this examination showed that IBLEO and Pn have antinociceptive 
      effects. The modulation of glutamatergic systems by opioid receptors could be 
      involved, at least in part, in these effects. Our data also suggest the 
      activation of the L-arginine/NO/cGMP/KATP pathway in IBLEO antinociceptive 
      effects.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Zarei, Mohammad
AU  - Zarei M
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
FAU - Mohammadi, Saeed
AU  - Mohammadi S
AD  - Department of Biology, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran. Electronic address: smiauhphd.sm@gmail.com.
FAU - Komaki, Alireza
AU  - Komaki A
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20180319
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Analgesics)
RN  - 0 (Chromones)
RN  - 9BNM33N01N (patuletin)
SB  - IM
MH  - Analgesics/isolation & purification/*pharmacology
MH  - Animals
MH  - Chromones/isolation & purification/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - *Inula
MH  - Male
MH  - Mice
MH  - Pain Measurement/*drug effects/*methods
OTO - NOTNLM
OT  - Diazepam
OT  - Glibenclamide
OT  - Glutamate
OT  - Inula britannica
OT  - L-arginine
OT  - Medicinal plants
OT  - Methylene blue
OT  - Morphine
OT  - Naloxonazine
OT  - Naloxone
OT  - Naltrindole
OT  - Nitroprusside sodium
OT  - Nor-binaltorphimine
OT  - Pain
OT  - Patuletin
OT  - PubChem CID: 10076594
OT  - PubChem CID: 11953895
OT  - PubChem CID: 33032
OT  - PubChem CID: 3488
OT  - PubChem CID: 39836
OT  - PubChem CID: 5288826
OT  - PubChem CID: 5464092
OT  - PubChem CID: 5480230
OT  - PubChem CID: 5497186
OT  - PubChem CID: 6099
OT  - PubChem CID: 6322
OT  - PubChem CID: 6452650
OT  - PubChem CID: 9576413
OT  - nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME)
EDAT- 2018/03/24 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/03/24 06:00
PHST- 2017/10/26 00:00 [received]
PHST- 2018/03/08 00:00 [revised]
PHST- 2018/03/16 00:00 [accepted]
PHST- 2018/03/24 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/03/24 06:00 [entrez]
AID - S0378-8741(17)33902-8 [pii]
AID - 10.1016/j.jep.2018.03.021 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2018 Jun 12;219:351-358. doi: 10.1016/j.jep.2018.03.021. Epub 
      2018 Mar 19.