PMID- 29568262
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240314
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 12
DP  - 2018
TI  - Dynamical Mechanism of Hyperpolarization-Activated Non-specific Cation Current 
      Induced Resonance and Spike-Timing Precision in a Neuronal Model.
PG  - 62
LID - 10.3389/fncel.2018.00062 [doi]
LID - 62
AB  - Hyperpolarization-activated cyclic nucleotide-gated cation current (I(h) ) plays 
      important roles in the achievement of many physiological/pathological functions 
      in the nervous system by modulating the electrophysiological activities, such as 
      the rebound (spike) to hyperpolarization stimulations, subthreshold membrane 
      resonance to sinusoidal currents, and spike-timing precision to stochastic 
      factors. In the present paper, with increasing g(h) (conductance of I(h) ), the 
      rebound (spike) and subthreshold resonance appear and become stronger, and the 
      variability of the interspike intervals (ISIs) becomes lower, i.e., the 
      enhancement of spike-timing precision, which are simulated in a conductance-based 
      theoretical model and well explained by the nonlinear concept of bifurcation. 
      With increasing g(h) , the stable node to stable focus, to coexistence behavior, 
      and to firing via the codimension-1 bifurcations (Hopf bifurcation, saddle-node 
      bifurcation, saddle-node bifurcations on an invariant circle, and saddle 
      homoclinic orbit) and codimension-2 bifurcations such as Bogdanov-Takens (BT) 
      point related to the transition between saddle-node and Hopf bifurcations, are 
      acquired with 1- and 2-parameter bifurcation analysis. The decrease of 
      variability of ISIs with increasing g(h) is induced by the fast decrease of the 
      standard deviation of ISIs, which is related to the increase of the capacity of 
      resisting noisy disturbance due to the firing becomes far away from the 
      bifurcation point. The enhancement of the rebound (spike) with increasing g(h) 
      builds up a relationship to the decrease of the capacity of resisting disturbance 
      like the hyperpolarization stimulus as the resting state approaches the 
      bifurcation point. The "typical"-resonance and non-resonance appear in the 
      parameter region of the stable focus and node far away from the bifurcation 
      points, respectively. The complex or "strange" dynamics, such as the 
      "weak"-resonance for the stable node near the transition point between the stable 
      node and focus and the non-resonance for the stable focus close to the 
      codimension-1 and -2 bifurcation points, are discussed.
FAU - Zhao, Zhiguo
AU  - Zhao Z
AD  - School of Aerospace Engineering and Applied Mechanics, Tongji University, 
      Shanghai, China.
AD  - School of Basic Science, Henan Institute of Technology, Xinxiang, China.
FAU - Li, Li
AU  - Li L
AD  - School of Aerospace Engineering and Applied Mechanics, Tongji University, 
      Shanghai, China.
FAU - Gu, Huaguang
AU  - Gu H
AD  - School of Aerospace Engineering and Applied Mechanics, Tongji University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20180308
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC5852126
OTO - NOTNLM
OT  - bifurcations
OT  - hyperpolarization-activated current
OT  - post-inhibitory rebound
OT  - spike-timing precision
OT  - subthreshold resonance
OT  - temporal coding
EDAT- 2018/03/24 06:00
MHDA- 2018/03/24 06:01
PMCR- 2018/01/01
CRDT- 2018/03/24 06:00
PHST- 2017/10/27 00:00 [received]
PHST- 2018/02/20 00:00 [accepted]
PHST- 2018/03/24 06:00 [entrez]
PHST- 2018/03/24 06:00 [pubmed]
PHST- 2018/03/24 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2018.00062 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2018 Mar 8;12:62. doi: 10.3389/fncel.2018.00062. eCollection 
      2018.