PMID- 29568481
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2090-8040 (Print)
IS  - 2042-0099 (Electronic)
IS  - 2042-0099 (Linking)
VI  - 2018
DP  - 2018
TI  - Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus.
PG  - 2157434
LID - 10.1155/2018/2157434 [doi]
LID - 2157434
AB  - Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching 
      epidemic levels. High susceptibility to infections of T2DM patients indicates 
      dysregulated immune responses to pathogens. However, innate immune responses, 
      including monocyte functions, in T2DM are poorly investigated. Therefore, in this 
      study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of 
      circulating monocytes from T2DM patients. The results showed that monocytes from 
      T2DM were hyporesponsive to LPS challenge as reflected by significantly 
      suppressed secretion of TNFalpha (p < 0.01) and expression of CD11b (p < 0.001) and 
      TLR4 (p < 0.001) compared to those in monocytes from healthy subjects. 
      Furthermore, LPS-induced IL-10 levels were similar in diabetic and healthy 
      supernatants, while expression levels of CD163 were found to be downregulated on 
      monocytes from T2DM (p < 0.001) suggesting impaired ability of monocytes to 
      switch their phenotype to anti-inflammatory. Taken together, our results suggest 
      compromised function of monocytes in T2DM, which may explain, at least partly, 
      high incidence of infection in these patients.
FAU - Khondkaryan, Lusine
AU  - Khondkaryan L
AD  - Group of Cell Technologies, Institute of Molecular Biology, National Academy of 
      Sciences, Yerevan, Armenia.
FAU - Margaryan, Sona
AU  - Margaryan S
AD  - Laboratory of Molecular and Cellular Immunology, Institute of Molecular Biology, 
      National Academy of Sciences, Yerevan, Armenia.
AD  - Russian-Armenian (Slavonic) University, Yerevan, Armenia.
FAU - Poghosyan, David
AU  - Poghosyan D
AD  - Laboratory of Molecular and Cellular Immunology, Institute of Molecular Biology, 
      National Academy of Sciences, Yerevan, Armenia.
FAU - Manukyan, Gayane
AU  - Manukyan G
AUID- ORCID: 0000-0001-7541-5743
AD  - Laboratory of Molecular and Cellular Immunology, Institute of Molecular Biology, 
      National Academy of Sciences, Yerevan, Armenia.
AD  - Russian-Armenian (Slavonic) University, Yerevan, Armenia.
LA  - eng
PT  - Journal Article
DEP - 20180114
PL  - United States
TA  - Int J Inflam
JT  - International journal of inflammation
JID - 101538188
PMC - PMC5820544
EDAT- 2018/03/24 06:00
MHDA- 2018/03/24 06:01
PMCR- 2018/01/14
CRDT- 2018/03/24 06:00
PHST- 2017/10/12 00:00 [received]
PHST- 2017/12/14 00:00 [accepted]
PHST- 2018/03/24 06:00 [entrez]
PHST- 2018/03/24 06:00 [pubmed]
PHST- 2018/03/24 06:01 [medline]
PHST- 2018/01/14 00:00 [pmc-release]
AID - 10.1155/2018/2157434 [doi]
PST - epublish
SO  - Int J Inflam. 2018 Jan 14;2018:2157434. doi: 10.1155/2018/2157434. eCollection 
      2018.