PMID- 29568518 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220316 IS - 2047-9158 (Print) IS - 2047-9158 (Electronic) IS - 2047-9158 (Linking) VI - 7 DP - 2018 TI - Exercise-induced increase in brain-derived neurotrophic factor in human Parkinson's disease: a systematic review and meta-analysis. PG - 7 LID - 10.1186/s40035-018-0112-1 [doi] LID - 7 AB - BACKGROUND: Animal models of exercise and Parkinson's disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic factor (BDNF). No reviews so far have assessed the methodologic quality of available intervention studies or have bundled the effect sizes of individual studies on exercise-induced effects on BDNF blood levels in human PD. RESEARCH DESIGN AND METHODS: We searched MEDLINE, EMBASE, Cochrane Library, PsycINFO and PubMed from inception to June 2017. RESULTS: Data aggregated from two randomized controlled trials and four pre-experimental studies with a total of 100 ambulatory patients with idiopathic PD (Hoehn/Yahr