PMID- 29569403
OWN - NLM
STAT- MEDLINE
DCOM- 20190614
LR  - 20200225
IS  - 1521-0391 (Electronic)
IS  - 1055-0496 (Print)
IS  - 1055-0496 (Linking)
VI  - 27
IP  - 3
DP  - 2018 Apr
TI  - Generalizability of the findings from a randomized controlled trial of a 
      web-based substance use disorder intervention.
PG  - 231-237
LID - 10.1111/ajad.12714 [doi]
AB  - BACKGROUND AND OBJECTIVES: There is growing concern regarding the 
      generalizability of findings from randomized controlled trials (RCTs) of 
      interventions for substance use disorders (SUDs). This study used a selection 
      model approach to assess and improve the generalizability of an evaluation for a 
      web-based SUD intervention by making the trial sample resemble the target 
      population. METHODS: The sample of the web-based SUD intervention (Therapeutic 
      Education System vs. Treatment-as-usual; n = 507) was compared with the target 
      population of SUD treatment-seeking individuals from the Treatment Episodes Data 
      Set-Admissions (TEDS-A). Using weights based on the probabilities of RCT 
      participation, we computed weighted treatment effects on retention and 
      abstinence. RESULTS: Substantial differences between the RCT sample and the 
      target population was demonstrated in significant difference in the mean 
      propensity scores (1.62 standard deviations at p < .001). The population effect 
      on abstinence (12 weeks and 6 months) was statistically insignificant after 
      weighting the data with the generalizability weight. DISCUSSIONS AND CONCLUSIONS: 
      Generalizability of the findings from the RCT could be limited when the RCT 
      sample does not well represent the target population. SCIENTIFIC SIGNIFICANCE: 
      Application of generalizability weights can be a potentially useful tool to 
      improve generalizability of RCT findings. (Am J Addict 2018;27:231-237).
CI  - (c) 2018 American Academy of Addiction Psychiatry.
FAU - Susukida, Ryoko
AU  - Susukida R
AUID- ORCID: 0000-0003-0444-5368
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      624 N. Broadway, Baltimore, Maryland 21205.
AD  - Department of Mental Health Policy and Evaluation, National Center of Neurology 
      and Psychiatry, National Institute of Mental Health, 4-1-1 Ogawa-Higashi, 
      Kodaira, Tokyo 187-8551, Japan.
FAU - Crum, Rosa M
AU  - Crum RM
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      624 N. Broadway, Baltimore, Maryland 21205.
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 
      615 N. Wolfe St., Baltimore, Maryland 21205.
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, 600 N. Wolfe St., Baltimore, Maryland 21287.
FAU - Stuart, Elizabeth A
AU  - Stuart EA
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      624 N. Broadway, Baltimore, Maryland 21205.
AD  - Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 
      615 N. Broadway, Baltimore, Maryland 21205.
AD  - Department of Health Policy and Management, Johns Hopkins Bloomberg School of 
      Public Health, 624 N. Broadway, Baltimore, Maryland 21205.
FAU - Mojtabai, Ramin
AU  - Mojtabai R
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      624 N. Broadway, Baltimore, Maryland 21205.
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, 600 N. Wolfe St., Baltimore, Maryland 21287.
LA  - eng
GR  - R01 DA036520/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20180323
PL  - England
TA  - Am J Addict
JT  - The American journal on addictions
JID - 9208821
SB  - IM
MH  - Adult
MH  - Bias
MH  - Computer Communication Networks
MH  - Data Collection/methods
MH  - Education, Distance/*methods
MH  - Female
MH  - Generalization, Psychological
MH  - *Help-Seeking Behavior
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Education as Topic/*methods
MH  - Patient Selection
MH  - *Substance-Related Disorders/psychology/therapy
MH  - Treatment Outcome
PMC - PMC6548718
MID - NIHMS1032354
EDAT- 2018/03/24 06:00
MHDA- 2019/06/15 06:00
PMCR- 2019/06/05
CRDT- 2018/03/24 06:00
PHST- 2017/08/25 00:00 [received]
PHST- 2017/12/22 00:00 [revised]
PHST- 2018/03/03 00:00 [accepted]
PHST- 2018/03/24 06:00 [pubmed]
PHST- 2019/06/15 06:00 [medline]
PHST- 2018/03/24 06:00 [entrez]
PHST- 2019/06/05 00:00 [pmc-release]
AID - 10.1111/ajad.12714 [doi]
PST - ppublish
SO  - Am J Addict. 2018 Apr;27(3):231-237. doi: 10.1111/ajad.12714. Epub 2018 Mar 23.