PMID- 29570803
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181022
IS  - 2042-7158 (Electronic)
IS  - 0022-3573 (Linking)
VI  - 70
IP  - 7
DP  - 2018 Jul
TI  - Facial hyperalgesia due to direct action of endothelin-1 in the trigeminal 
      ganglion of mice.
PG  - 893-900
LID - 10.1111/jphp.12905 [doi]
AB  - OBJECTIVE: This study assessed the ability of endothelin-1 (ET-1) to evoke heat 
      hyperalgesia when injected directly into the trigeminal ganglia (TG) of mice and 
      determined the receptors implicated in this effect. The effects of TG ET(A) and 
      ET(B) receptor blockade on alleviation of heat hyperalgesia in a model of 
      trigeminal neuropathic pain induced by infraorbital nerve constriction (CION) 
      were also examined. METHODS: Naive mice received an intraganglionar (i.g.) 
      injection of ET-1 (0.3-3 pmol) or the selective ET(B) R agonist sarafotoxin S6c 
      (3-30 pmol), and response latencies to ipsilateral heat stimulation were assessed 
      before the treatment and at 1-h intervals up to 5 h after the treatment. Heat 
      hyperalgesia induced by i.g. ET-1 or CION was assessed after i.g. injections of 
      ET(A) R and ET(B) R antagonists (BQ-123 and BQ-788, respectively, each at 0.5 
      nmol). KEY FINDINGS: Intraganglionar ET-1 or sarafotoxin S6c injection induced 
      heat hyperalgesia lasting 4 and 2 h, respectively. Heat hyperalgesia induced by 
      ET-1 was attenuated by i.g. BQ-123 or BQ-788. On day 5 after CION, i.g. BQ-788 
      injection produced a more robust antihyperalgesic effect compared with BQ-123. 
      CONCLUSIONS: ET-1 injection into the TG promotes ET(A) R/ET(B) R-mediated facial 
      heat hyperalgesia, and both receptors are clearly implicated in CION-induced 
      hyperalgesia in the murine TG system.
CI  - (c) 2018 Royal Pharmaceutical Society.
FAU - Gomes, Lenyta Oliveira
AU  - Gomes LO
AD  - Department of Pharmacology, Center of Biological Sciences, Federal University of 
      Santa Catarina, Florianopolis , Santa Catarina, Brazil.
FAU - Chichorro, Juliana Geremias
AU  - Chichorro JG
AUID- ORCID: 0000-0001-5345-141X
AD  - Department of Pharmacology, Biological Sciences Sector, Federal University of 
      Parana, Curitiba , Parana, Brazil.
FAU - Araya, Erika Ivanna
AU  - Araya EI
AD  - Department of Pharmacology, Biological Sciences Sector, Federal University of 
      Parana, Curitiba , Parana, Brazil.
FAU - de Oliveira, Jade
AU  - de Oliveira J
AD  - Department of Biochemistry, Center of Biological Sciences, Federal University of 
      Santa Catarina, Florianopolis, Santa Catarina, Brazil.
FAU - Rae, Giles Alexander
AU  - Rae GA
AD  - Department of Pharmacology, Center of Biological Sciences, Federal University of 
      Santa Catarina, Florianopolis , Santa Catarina, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180323
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Endothelin A Receptor Antagonists)
RN  - 0 (Endothelin-1)
RN  - 0 (Oligopeptides)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Piperidines)
RN  - 0 (Receptor, Endothelin A)
RN  - 0 (Receptor, Endothelin B)
RN  - 0 (Viper Venoms)
RN  - 0 (sarafotoxins s6)
RN  - 44OLL8XEJ4 (BQ 788)
RN  - S2A8YZM151 (cyclo(Trp-Asp-Pro-Val-Leu))
SB  - IM
MH  - Animals
MH  - Constriction
MH  - Dose-Response Relationship, Drug
MH  - Endothelin A Receptor Antagonists/pharmacology
MH  - Endothelin-1/*pharmacology
MH  - Hyperalgesia/*chemically induced/physiopathology
MH  - Male
MH  - Mice
MH  - Oligopeptides/pharmacology
MH  - Pain Measurement/drug effects
MH  - Peptides, Cyclic/pharmacology
MH  - Piperidines/pharmacology
MH  - Receptor, Endothelin A/physiology
MH  - Receptor, Endothelin B/agonists/physiology
MH  - Trigeminal Ganglion/drug effects/*physiology
MH  - Viper Venoms/pharmacology
OTO - NOTNLM
OT  - ETA receptor
OT  - ETB receptor
OT  - heat hyperalgesia
OT  - trigeminal ganglion
EDAT- 2018/03/24 06:00
MHDA- 2018/10/23 06:00
CRDT- 2018/03/24 06:00
PHST- 2017/08/24 00:00 [received]
PHST- 2018/02/10 00:00 [accepted]
PHST- 2018/03/24 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/03/24 06:00 [entrez]
AID - 10.1111/jphp.12905 [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 2018 Jul;70(7):893-900. doi: 10.1111/jphp.12905. Epub 2018 Mar 
      23.