PMID- 29571602
OWN - NLM
STAT- MEDLINE
DCOM- 20191126
LR  - 20220408
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Print)
IS  - 1053-2498 (Linking)
VI  - 37
IP  - 7
DP  - 2018 Jul
TI  - Heart failure after the Norwood procedure: An analysis of the Single Ventricle 
      Reconstruction Trial.
PG  - 879-885
LID - S1053-2498(18)31359-7 [pii]
LID - 10.1016/j.healun.2018.02.009 [doi]
AB  - BACKGROUND: Heart failure results in significant morbidity and mortality in young 
      children with hypoplastic left heart syndrome (HLHS) after the Norwood procedure. 
      METHODS: We studied subjects enrolled in the prospective Single Ventricle 
      Reconstruction (SVR) Trial who survived to hospital discharge after a Norwood 
      operation and were followed up to age 6 years. The primary outcome was heart 
      failure, defined as heart transplant listing after Norwood hospitalization, death 
      attributable to heart failure, or symptomatic heart failure (New York Heart 
      Association [NYHA] Class IV). Multivariate modeling was undertaken using Cox 
      regression methodology to determine variables associated with heart failure. 
      RESULTS: Of the 461 subjects discharged home following a Norwood procedure, 66 
      (14.3%) met the criteria for heart failure. Among these, 15 died from heart 
      failure, 39 were listed for transplant (22 had a transplant, 12 died after 
      listing, and 5 were alive and not yet transplanted), and 12 had NYHA Class IV 
      heart failure but were never listed. The median age at heart failure 
      identification was 1.28 (interquartile range 0.30 to 4.69) years. Factors 
      associated with early heart failure included post-Norwood lower fractional area 
      change, need for extracorporeal membrane oxygenation, non-Hispanic ethnicity, 
      Norwood perfusion type, and total support time (p < 0.05). CONCLUSIONS: By 6 
      years of age, heart failure developed in nearly 15% of children after the Norwood 
      procedure. Although transplant listing was common, many patients died from heart 
      failure before receiving a transplant or without being listed. Shunt type did not 
      impact the risk of developing heart failure.
CI  - Copyright (c) 2018 International Society for Heart and Lung Transplantation. All 
      rights reserved.
FAU - Mahle, William T
AU  - Mahle WT
AD  - Children's Healthcare of Atlanta and Department of Pediatrics, Division of 
      Cardiology Emory University Atlanta, GA (W.T.M). Electronic address: 
      wmahle@emory.edu.
FAU - Hu, Chenwei
AU  - Hu C
AD  - New England Research Institutes, Watertown, MA (F.T., C.H.).
FAU - Trachtenberg, Felicia
AU  - Trachtenberg F
AD  - New England Research Institutes, Watertown, MA (F.T., C.H.).
FAU - Menteer, JonDavid
AU  - Menteer J
AD  - Children's Hospital Los Angeles and Department of Pediatrics, Division of 
      Cardiology University of Southern California, Los Angeles, CA (J.M.).
FAU - Kindel, Steven J
AU  - Kindel SJ
AD  - Children's Hospital of Wisconsin, Milwaukee and Department of Pediatrics, 
      Division of Cardiology University of Wisconsin Milwaukee, WI (S.J.K.).
FAU - Dipchand, Anne I
AU  - Dipchand AI
AD  - The Hospital for Sick Children and Department of Pediatrics, Division of 
      Cardiology University of Toronto, Toronto, Ontario (A.I.D.).
FAU - Richmond, Marc E
AU  - Richmond ME
AD  - Morgan Stanley Children's Hospital of New York Presbyterian Columbia University 
      Medical Center and Department of Pediatrics, Division of Cardiology Columbia 
      University, New York, NY (M.E.R.).
FAU - Daly, Kevin P
AU  - Daly KP
AD  - Boston Children's Hospital and Department of Pediatrics Cardiology Harvard School 
      of Medicine, Boston, MA (K.PD., J.W.N.).
FAU - Henderson, Heather T
AU  - Henderson HT
AD  - Duke University Hospital and Department of Pediatrics, Division of Cardiology 
      Duke University, Durham, NC (H.T.H.).
FAU - Lin, Kimberly Y
AU  - Lin KY
AD  - Children's Hospital of Philadelphia and Department of Pediatrics, Division of 
      Cardiology University of Pennsylvania, Philadelphia, PA (K.L.).
FAU - McCulloch, Michael
AU  - McCulloch M
AD  - Alfred I. DuPont Hospital for Children and Department of Pediatrics, Division of 
      Cardiology Thomas Jefferson University, Wilmington, DE (M.M.).
FAU - Lal, Ashwin K
AU  - Lal AK
AD  - Primary Children's Medical Center and Department of Pediatrics, Division of 
      Cardiology University of Utah, Salt Lake City, UT (A.K.L.).
FAU - Schumacher, Kurt R
AU  - Schumacher KR
AD  - University of Michigan Health System and Department of Pediatrics, Division of 
      Cardiology University of Michigan, Ann Arbor, MI (K.S.).
FAU - Jacobs, Jeffrey P
AU  - Jacobs JP
AD  - Johns Hopkins All Children's Heart Institute and Department of Surgery, Division 
      of Cardiothoracic Surgery, St. Petersburg, FL (J.P.J.).
FAU - Atz, Andrew M
AU  - Atz AM
AD  - Department of Pediatrics, Division of Cardiology Medical University of South 
      Carolina, Charleston, SC (A.M.A.).
FAU - Villa, Chet R
AU  - Villa CR
AD  - Cincinnati Children's Hospital Medical Center and Department of Pediatrics, 
      Division of Cardiology University of Cincinnati, Cincinnati, OH (C.R.V.).
FAU - Burns, Kristin M
AU  - Burns KM
AD  - National Heart, Lung, and Blood Institute, Bethesda, MD (K.M.B.).
FAU - Newburger, Jane W
AU  - Newburger JW
AD  - Boston Children's Hospital and Department of Pediatrics Cardiology Harvard School 
      of Medicine, Boston, MA (K.PD., J.W.N.).
CN  - Pediatric Heart Network Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT00115934
GR  - UG1 HL135646/HL/NHLBI NIH HHS/United States
GR  - U10 HL109781/HL/NHLBI NIH HHS/United States
GR  - UG1 HL135685/HL/NHLBI NIH HHS/United States
GR  - U01 HL068269/HL/NHLBI NIH HHS/United States
GR  - U01 HL068279/HL/NHLBI NIH HHS/United States
GR  - UG1 HL135689/HL/NHLBI NIH HHS/United States
GR  - U01 HL068290/HL/NHLBI NIH HHS/United States
GR  - UG1 HL135682/HL/NHLBI NIH HHS/United States
GR  - U01 HL068288/HL/NHLBI NIH HHS/United States
GR  - U10 HL068270/HL/NHLBI NIH HHS/United States
GR  - U01 HL068281/HL/NHLBI NIH HHS/United States
GR  - U01 HL068270/HL/NHLBI NIH HHS/United States
GR  - U01 HL068292/HL/NHLBI NIH HHS/United States
GR  - U01 HL085057/HL/NHLBI NIH HHS/United States
GR  - U10 HL109778/HL/NHLBI NIH HHS/United States
GR  - UG1 HL135678/HL/NHLBI NIH HHS/United States
GR  - U01 HL068285/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180216
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Follow-Up Studies
MH  - Heart Failure/epidemiology/*etiology
MH  - Humans
MH  - Hypoplastic Left Heart Syndrome/*surgery
MH  - Infant
MH  - Norwood Procedures/*adverse effects
MH  - Postoperative Complications/epidemiology/*etiology
MH  - Prospective Studies
MH  - Time Factors
PMC - PMC6015519
MID - NIHMS953253
OTO - NOTNLM
OT  - Norwood procedure
OT  - cardiac surgery
OT  - congenital heart defect
OT  - congenital heart disease
OT  - single ventricle
COIS- Disclosure Statement: The authors have no conflicts of interest to disclose.
EDAT- 2018/03/25 06:00
MHDA- 2019/11/27 06:00
PMCR- 2019/07/01
CRDT- 2018/03/25 06:00
PHST- 2017/10/04 00:00 [received]
PHST- 2018/02/13 00:00 [revised]
PHST- 2018/02/14 00:00 [accepted]
PHST- 2018/03/25 06:00 [pubmed]
PHST- 2019/11/27 06:00 [medline]
PHST- 2018/03/25 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - S1053-2498(18)31359-7 [pii]
AID - 10.1016/j.healun.2018.02.009 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2018 Jul;37(7):879-885. doi: 
      10.1016/j.healun.2018.02.009. Epub 2018 Feb 16.