PMID- 29571823
OWN - NLM
STAT- MEDLINE
DCOM- 20190409
LR  - 20211204
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 677
DP  - 2018 Jun 11
TI  - Dexmedetomidine promotes the recovery of neurogenesis in aged mouse with 
      postoperative cognitive dysfunction.
PG  - 110-116
LID - S0304-3940(18)30220-9 [pii]
LID - 10.1016/j.neulet.2018.03.043 [doi]
AB  - Recently, growing evidence has demonstrated Dexmedetomidine (Dex) a promising 
      intervene preventing postoperative cognitive decline (POCD) following surgery, 
      which is associated with neuroinflammation leading to neuronal apoptosis and 
      deregulated neurogenesis. Previous studies suggested the anti-inflammation and 
      anti-neuroapoptosis action of Dex. Therefore we hypothesize the promoting 
      neurogenesis of Dex linked to stimulating BDNF and subsequent p-MPAK production 
      in a rat model of POCD. In the present study, the POCD animal model was 
      established by performing an exploratory laparotomy under isoflurane anaesthesia 
      in old rats, utilizing which Dex response is confirmed by behavioural tests. 
      Inflammatory biomarkers as IL-1beta and TNF-alpha, mature neuron percentage measured by 
      doublecortin staining (DCX), promoting factors as brain derived growth factor 
      (BDNF), phosphorylated cAMP response element binding protein (CREB) and proteins 
      of kinase A (PKA), MAPK production as p-P38-MAPK protein express were measured. 
      Herein, we showed that surgery reduced DCX-positive neurons and expression of 
      BDNF representing neurogenesis profoundly. As expected, Dex rescued the 
      associated cognitive impairment and inflammatory changes, as well as up-regulated 
      expression of BDNF, PKA, p-CREB/CREB and following p-P38-MAPK regulation. Our 
      results confirmed the protective Dex response and indicated the proneurogenesis 
      role of it as well, suggesting the mechanism of beneficial effects of Dex to 
      prevent POCD.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Wang, Wen-Xiang
AU  - Wang WX
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: 1012661313@qq.com.
FAU - Wu, Qiong
AU  - Wu Q
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: 1120524950@qq.com.
FAU - Liang, Si-Si
AU  - Liang SS
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: 867373330@qq.com.
FAU - Zhang, Xue-Kang
AU  - Zhang XK
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: kang7139@163.com.
FAU - Hu, Qian
AU  - Hu Q
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: 1213738002@qq.com.
FAU - Chen, Qiu-Hong
AU  - Chen QH
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: 1473769036@qq.com.
FAU - Huang, Hai-Jin
AU  - Huang HJ
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: huanghaijin1999@126.com.
FAU - Xu, Lin
AU  - Xu L
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: xlnc110@126.com.
FAU - Lou, Fo-Quan
AU  - Lou FQ
AD  - Department of Anesthesiology, First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi 330006, China. Electronic address: fqlzxmc@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180320
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Dcx protein, mouse)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 67VB76HONO (Dexmedetomidine)
SB  - IM
MH  - Animals
MH  - Cognitive Dysfunction/etiology/*prevention & control
MH  - Dexmedetomidine/*administration & dosage
MH  - Doublecortin Protein
MH  - Encephalitis/etiology/metabolism
MH  - Hippocampus/drug effects/physiology
MH  - Male
MH  - Neurogenesis/*drug effects
MH  - Neurons/*drug effects/physiology
MH  - Neuroprotective Agents/*administration & dosage
MH  - Postoperative Complications/*prevention & control
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction
MH  - Spatial Memory/drug effects
OTO - NOTNLM
OT  - Dexmedetomidine
OT  - Neurogenesis
OT  - Postoperative cognitive dysfunction
EDAT- 2018/03/25 06:00
MHDA- 2019/04/10 06:00
CRDT- 2018/03/25 06:00
PHST- 2017/08/14 00:00 [received]
PHST- 2018/03/17 00:00 [revised]
PHST- 2018/03/19 00:00 [accepted]
PHST- 2018/03/25 06:00 [pubmed]
PHST- 2019/04/10 06:00 [medline]
PHST- 2018/03/25 06:00 [entrez]
AID - S0304-3940(18)30220-9 [pii]
AID - 10.1016/j.neulet.2018.03.043 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Jun 11;677:110-116. doi: 10.1016/j.neulet.2018.03.043. Epub 
      2018 Mar 20.