PMID- 29572131
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20190325
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 87
DP  - 2018 Oct
TI  - Oxidative stress-mediated influence of plasma DPP4 activity to BDNF ratio on mild 
      cognitive impairment in elderly type 2 diabetic patients: results from the GDMD 
      study in China.
PG  - 105-112
LID - S0026-0495(18)30086-6 [pii]
LID - 10.1016/j.metabol.2018.03.014 [doi]
AB  - OBJECTIVE: Increased dipeptidyl peptidase-4 (DPP4) activity and reduced 
      brain-derived neurotrophic factor (BDNF) in peripheral circulation are both 
      associated with a high risk of mild cognitive impairment (MCI) in the elderly. 
      Hence, we aimed to investigate the association between plasma DPP4 activity to 
      BDNF ratio (DBR) and MCI in elderly patients with type 2 diabetes. DESIGN AND 
      METHODS: We measured plasma DPP4 activity, BDNF levels, oxidative stress 
      parameters, inflammatory markers and calculated DBR in 1833 elderly type 2 
      diabetic patients aged 60 years or older. MCI was diagnosed according to the 
      National Institute on Aging-Alzheimer's Association workgroups criteria. Further, 
      mediation analysis was performed to estimate the mediator role of oxidative 
      stress on the relationship between DPP4 activity and BDNF. RESULTS: DPP4 activity 
      was negatively associated with BDNF (r = -0.408, P < 0.001). Oxidative stress, 
      particularly in male participants, acted as a partial mediator in the 
      relationship between DPP4 activity and BDNF. Participants in the highest quartile 
      of DBR had higher nitrotyrosine, 8-isoPGF2a, interleukin-6, C-reactive protein 
      and lower Montreal Cognitive Assessment score compared with those in the lowest 
      quartile. The odds ratio (5.15, 95% CI 3.64-7.30) for MCI in the highest DBR 
      quartile was significantly higher than in the lowest quartile. The risk for MCI 
      increased with higher levels of DPP4 activity and lower levels of BDNF. 
      CONCLUSIONS: Oxidative stress partially mediates the inverse relationship between 
      DPP4 and BDNF. Our data provide evidence for a strong link between DBR and MCI, 
      suggesting DBR to be a new biomarker for MCI in type 2 diabetic patients.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Zheng, Tianpeng
AU  - Zheng T
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Guilin Medical University, Guilin, Guangxi, PR China; Center of Diabetic Systems 
      Medicine, Guilin Medical University, Guilin, Guangxi, PR China. Electronic 
      address: w19831120@126.com.
FAU - Liu, Hongbo
AU  - Liu H
AD  - Department of laboratory medicine, The Second Affiliated Hospital of Guilin 
      Medical University, Guilin, Guangxi, PR China.
FAU - Qin, Linyuan
AU  - Qin L
AD  - Department of Epidemiology and Health Statistics, Guilin Medical University, 
      Guilin, Guangxi, PR China.
FAU - Chen, Bo
AU  - Chen B
AD  - Research Center of Combined Traditional Chinese and Western Medicine, Affiliated 
      Traditional Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 
      PR China; Department of Human Anatomy, Southwest Medical University, Luzhou, 
      Sichuan, PR China.
FAU - Zhang, Xiaoxi
AU  - Zhang X
AD  - Center of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi, 
      PR China.
FAU - Hu, Xueping
AU  - Hu X
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Guilin Medical University, Guilin, Guangxi, PR China.
FAU - Xiao, Liuping
AU  - Xiao L
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Guilin Medical University, Guilin, Guangxi, PR China.
FAU - Qin, Shenghua
AU  - Qin S
AD  - Medical Examination Center, Affiliated Hospital of Guilin Medical University, 
      Guilin, Guangxi, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180321
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 3.4.14.5 (DPP4 protein, human)
RN  - EC 3.4.14.5 (Dipeptidyl Peptidase 4)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - China
MH  - Cognitive Dysfunction/complications/*metabolism/psychology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Dipeptidyl Peptidase 4/*blood
MH  - Female
MH  - Humans
MH  - Inflammation/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Oxidative Stress/*physiology
MH  - Sex Characteristics
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - DPP4 activity to BDNF ratio
OT  - Dipeptidyl peptidase-4
OT  - Inflammation
OT  - Mild cognitive impairment
OT  - Oxidative stress
OT  - Type 2 diabetes
EDAT- 2018/03/25 06:00
MHDA- 2019/03/26 06:00
CRDT- 2018/03/25 06:00
PHST- 2017/10/13 00:00 [received]
PHST- 2018/02/26 00:00 [revised]
PHST- 2018/03/16 00:00 [accepted]
PHST- 2018/03/25 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2018/03/25 06:00 [entrez]
AID - S0026-0495(18)30086-6 [pii]
AID - 10.1016/j.metabol.2018.03.014 [doi]
PST - ppublish
SO  - Metabolism. 2018 Oct;87:105-112. doi: 10.1016/j.metabol.2018.03.014. Epub 2018 
      Mar 21.