PMID- 29573490
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20211204
IS  - 1365-2613 (Electronic)
IS  - 0959-9673 (Print)
IS  - 0959-9673 (Linking)
VI  - 99
IP  - 1
DP  - 2018 Feb
TI  - Extracellular matrix internalization links nutrient signalling to invasive 
      migration.
PG  - 4-9
LID - 10.1111/iep.12265 [doi]
AB  - Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, 
      linking the ECM to the actin cytoskeleton. Besides localizing at the cell 
      surface, they can be internalized and transported back to the plasma membrane 
      (recycled) or delivered to the late endosomes/lysosomes for degradation. We and 
      others have shown that integrin can be endocytosed together with their ECM 
      ligands. In this short review, I will highlight how extracellular protein 
      (including ECM) endocytosis impinges on the activation of the mechanistic target 
      of rapamycin (mTOR) pathway, a master regulator of cell metabolism and growth. 
      This supports the intriguing hypothesis that ECM components may be considered as 
      nutrient sources, primarily under soluble nutrient-depleted conditions.
CI  - (c) 2018 The Authors. International Journal of Experimental Pathology (c) 2018 
      International Journal of Experimental Pathology.
FAU - Rainero, Elena
AU  - Rainero E
AUID- ORCID: 0000-0003-1402-8701
AD  - Biomedical Science Department, The University of Sheffield, Sheffield, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180324
PL  - England
TA  - Int J Exp Pathol
JT  - International journal of experimental pathology
JID - 9014042
RN  - 0 (Integrins)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - *Cell Movement
MH  - *Endocytosis
MH  - *Energy Metabolism
MH  - Extracellular Matrix/*metabolism/pathology
MH  - Humans
MH  - Integrins/*metabolism
MH  - Neoplasm Invasiveness
MH  - Neoplasms/*metabolism/pathology
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Transport Vesicles/metabolism/pathology
PMC - PMC5917393
OTO - NOTNLM
OT  - mTOR
OT  - cell metabolism
OT  - extracellular matrix
OT  - integrins
OT  - nutrient signalling
OT  - vesicular trafficking
EDAT- 2018/03/25 06:00
MHDA- 2018/11/27 06:00
PMCR- 2019/02/01
CRDT- 2018/03/25 06:00
PHST- 2017/10/30 00:00 [received]
PHST- 2018/02/14 00:00 [accepted]
PHST- 2018/03/25 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/03/25 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - IEP12265 [pii]
AID - 10.1111/iep.12265 [doi]
PST - ppublish
SO  - Int J Exp Pathol. 2018 Feb;99(1):4-9. doi: 10.1111/iep.12265. Epub 2018 Mar 24.