PMID- 29574094
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20190401
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Linking)
VI  - 52
DP  - 2018 Jun
TI  - Regulation of human dendritic cell immune functions by ion channels.
PG  - 27-31
LID - S0952-7915(17)30111-5 [pii]
LID - 10.1016/j.coi.2018.03.011 [doi]
AB  - Dendritic cells (DCs) are highly specialized antigen-presenting cells (APCs) able 
      to induce both specific immunity and immune tolerance. Using information gathered 
      from the tissue where they reside, DCs adjust their functional activity to ensure 
      that protective immunity is favoured while unwanted or exaggerated immune 
      responses are prevented. The remarkable ability of these cells to induce, enhance 
      and orient the immune response, while at the same time maintaining 
      self-tolerance, makes them key players in the immune system. Despite the fact 
      that the role of Ca(2+) has been clearly established in human DC functions, the 
      link between ion homeostasis, mainly Ca(2+), and DC functions is not fully 
      understood. After all, a growing number of works clearly show the role of SOCE 
      and associated channels in the maturation step, and those of K(+) channels in 
      migration. This review highlights the key papers published over the past few 
      years and summarizes prospects for the near future.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Vandier, Christophe
AU  - Vandier C
AD  - UMR INSERM 1069 Nutrition, Croissance et Cancer, University Francois-Rabelais de 
      Tours, 10 Boulevard Tonnelle, F-37032 Tours, France.
FAU - Velge-Roussel, Florence
AU  - Velge-Roussel F
AD  - UMR CNRS 7292 GICC, University Francois-Rabelais de Tours, 10 Bd Tonnelle, 
      F-37032 Tours, France; UFR des Sciences Pharmaceutiques, Av Monge, F-37000 Tours, 
      France. Electronic address: velge@univ-tours.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180322
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Calcium Release Activated Calcium Channels)
RN  - 0 (Intermediate-Conductance Calcium-Activated Potassium Channels)
RN  - 0 (Ion Channels)
RN  - 0 (KCNN4 protein, human)
RN  - 0 (Transient Receptor Potential Channels)
SB  - IM
MH  - Animals
MH  - Calcium Release Activated Calcium Channels/genetics/metabolism
MH  - Cell Differentiation/genetics/immunology
MH  - Cell Movement/genetics/immunology
MH  - Dendritic Cells/cytology/*immunology/*metabolism
MH  - Humans
MH  - *Immunity/genetics
MH  - *Immunomodulation/genetics
MH  - Intermediate-Conductance Calcium-Activated Potassium Channels/genetics/metabolism
MH  - Ion Channels/genetics/*metabolism
MH  - Transient Receptor Potential Channels/genetics/metabolism
EDAT- 2018/03/27 06:00
MHDA- 2019/04/02 06:00
CRDT- 2018/03/26 06:00
PHST- 2018/01/09 00:00 [received]
PHST- 2018/03/05 00:00 [revised]
PHST- 2018/03/07 00:00 [accepted]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/03/26 06:00 [entrez]
AID - S0952-7915(17)30111-5 [pii]
AID - 10.1016/j.coi.2018.03.011 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2018 Jun;52:27-31. doi: 10.1016/j.coi.2018.03.011. Epub 2018 
      Mar 22.