PMID- 29574629
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20181217
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 55
IP  - 11
DP  - 2018 Nov
TI  - Exercise Rehabilitation Attenuates Cognitive Deficits in Rats with Traumatic 
      Brain Injury by Stimulating the Cerebral HSP20/BDNF/TrkB Signalling Axis.
PG  - 8602-8611
LID - 10.1007/s12035-018-1011-2 [doi]
AB  - Physical exercise (PE) is an effective method for improving cognitive function 
      among patients with traumatic brain injury (TBI). We previously demonstrated that 
      PE with an infrared-sensing running wheel (ISRW) system provides strong 
      neuroprotection in an experimental animal model of stroke. In this study, we used 
      fluid percussion injury in rats to simulate mild TBI. For rats, we used both 
      passive avoidance learning and the Y-maze tests to evaluate cognitive function. 
      We investigated whether PE rehabilitation attenuated cognitive deficits in rats 
      with TBI and determined the contribution of hippocampal and cortical expression 
      of heat shock protein 20 (HSP20) to PE-mediated cognitive recovery. In addition 
      to increasing hippocampal and cortical expression of HSP20, brain-derived 
      neurotrophic factor (BDNF), and the tropomyosin receptor kinase B (TrkB) ratio, 
      PE rehabilitation significantly attenuated brain contusion and improved cognitive 
      deficits in the rat model. Furthermore, reducing hippocampal and cortical 
      expression of HSP20 with an intracerebral injection of pSUPER hsp20 small 
      interfering RNA significantly diminished the PE-induced overexpression of 
      hippocampal and cortical BDNF and the TrkB ratio and also reversed the beneficial 
      effect of PE in reducing neurotrauma and the cognitive deficits. A positive 
      Pearson correlation was found between HSP20 and BDNF, as well as between HSP20 
      and TrkB, in the hippocampal and cortical tissues. We thus conclude that 
      post-ischaemic ISRW exercise rehabilitation attenuates cognitive deficits, as 
      well as brain contusions, in TBI rats by stimulating the cerebral HSP20/BDNF/TrkB 
      signalling axis.
FAU - Chou, Willy
AU  - Chou W
AD  - Department of Physical Medicine and Rehabilitation, Chi Mei Medical Center, 
      Tainan, 710, Taiwan.
AD  - Department of Recreation and Healthcare Management, Chia Nan University of 
      Pharmacy and Science, Tainan, 71710, Taiwan.
FAU - Liu, Yu-Fan
AU  - Liu YF
AD  - Department of Medical Research, Chi Mei Medical Center, Tainan, 710, Taiwan.
AD  - Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574, 
      Ibaraki, Japan.
FAU - Lin, Cheng-Hsien
AU  - Lin CH
AD  - Department of Medical Research, Chi Mei Medical Center, Tainan, 710, Taiwan.
AD  - Department of Leisure, Recreation, and Tourism Management, Southern Taiwan 
      University of Science and Technology, Tainan, 710, Taiwan.
FAU - Lin, Mao-Tsun
AU  - Lin MT
AD  - Department of Medical Research, Chi Mei Medical Center, Tainan, 710, Taiwan.
FAU - Chen, Chi-Chun
AU  - Chen CC
AD  - Department of Electronic Engineering, National Chin-Yi University of Technology, 
      Taichung, 41170, Taiwan.
FAU - Liu, Wen-Pin
AU  - Liu WP
AD  - Department of Medical Research, Chi Mei Medical Center, Tainan, 710, Taiwan.
FAU - Chang, Ching-Ping
AU  - Chang CP
AUID- ORCID: 0000-0003-0890-9414
AD  - Department of Medical Research, Chi Mei Medical Center, Tainan, 710, Taiwan. 
      jessica.cpchang@gmail.com.
FAU - Chio, Chung-Ching
AU  - Chio CC
AD  - Division of Neurosurgery, Department of Surgery, Chi Mei Medical Center, Tainan, 
      710, Taiwan. chiocc@ms28.hinet.net.
LA  - eng
GR  - MOST 104-2314-B-384 -003 -MY3/Ministry of Science and Technology, Taiwan/
GR  - MOST 106-2314-B-384-001-MY3/Ministry of Science and Technology, Taiwan/
GR  - CMFHT 10504/Chi Mei Medical Center/
PT  - Journal Article
DEP - 20180325
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (HSP20 Heat-Shock Proteins)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain Contusion/metabolism/pathology
MH  - Brain Injuries, Traumatic/*complications/*rehabilitation
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition Disorders/*metabolism/*rehabilitation
MH  - HSP20 Heat-Shock Proteins/*metabolism
MH  - Hippocampus/metabolism/pathology
MH  - Male
MH  - *Physical Conditioning, Animal
MH  - RNA Interference
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Heat shock protein 20
OT  - Physical exercise
OT  - Traumatic brain injury
EDAT- 2018/03/27 06:00
MHDA- 2018/12/18 06:00
CRDT- 2018/03/26 06:00
PHST- 2017/09/15 00:00 [received]
PHST- 2018/03/16 00:00 [accepted]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/03/26 06:00 [entrez]
AID - 10.1007/s12035-018-1011-2 [pii]
AID - 10.1007/s12035-018-1011-2 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2018 Nov;55(11):8602-8611. doi: 10.1007/s12035-018-1011-2. Epub 
      2018 Mar 25.