PMID- 29574652
OWN - NLM
STAT- MEDLINE
DCOM- 20181114
LR  - 20200401
IS  - 1619-0904 (Electronic)
IS  - 1434-7229 (Print)
IS  - 1434-7229 (Linking)
VI  - 21
IP  - 3
DP  - 2018 Sep
TI  - Extracorporeal life support for immune reconstitution inflammatory syndrome in 
      HIV patients with Pneumocystis jirovecii pneumonia.
PG  - 371-373
LID - 10.1007/s10047-018-1036-3 [doi]
AB  - Patients with immunosuppression from human immunodeficiency virus (HIV) have been 
      traditionally considered poor candidates for extracorporeal membrane oxygenation 
      (ECMO) because of high in-hospital mortality and poor long-term survival. Highly 
      active antiretroviral therapy (HAART) has improved survival rates in compliant 
      HIV patients and reversible severe respiratory failure may warrant ECMO in this 
      group. Immune reconstitution inflammatory syndrome (IRIS) involves excessive 
      inflammatory response to a pathogen with paradoxical clinical deterioration 
      following HAART initiation and may present as severe respiratory failure. 
      Patients with IRIS supported on ECMO have been infrequently reported in 
      literature. We report two HIV-positive patients who developed acute respiratory 
      distress syndrome from IRIS necessitating successful veno-venous ECMO as salvage 
      therapy.
FAU - Ramanathan, Kollengode
AU  - Ramanathan K
AUID- ORCID: 0000-0003-1822-9455
AD  - Department of Cardiothoracic and Vascular Surgery, National University Hospital, 
      1 E Kent Ridge road, NUHS Tower Block, Level 9, Singapore, 119228, Singapore. 
      ram_ramanathan@nuhs.edu.sg.
AD  - Department of Surgery, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore. ram_ramanathan@nuhs.edu.sg.
FAU - Svasti, Julian K
AU  - Svasti JK
AD  - Department of Surgery, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - MacLaren, Graeme
AU  - MacLaren G
AD  - Department of Cardiothoracic and Vascular Surgery, National University Hospital, 
      1 E Kent Ridge road, NUHS Tower Block, Level 9, Singapore, 119228, Singapore.
AD  - Department of Surgery, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180324
PL  - Japan
TA  - J Artif Organs
JT  - Journal of artificial organs : the official journal of the Japanese Society for 
      Artificial Organs
JID - 9815648
SB  - IM
MH  - Adult
MH  - *Extracorporeal Membrane Oxygenation
MH  - HIV Infections/*complications/immunology
MH  - Humans
MH  - *Immune Reconstitution
MH  - Male
MH  - Pneumonia, Pneumocystis/etiology/immunology/*therapy
MH  - Respiratory Insufficiency
MH  - Treatment Outcome
PMC - PMC7101969
OTO - NOTNLM
OT  - Extracorporeal membrane oxygenation (ECMO)
OT  - HIV
OT  - Immune reconstitution
COIS- No potential conflict of interest relevant to this article was reported by the 
      authors.
EDAT- 2018/03/27 06:00
MHDA- 2018/11/15 06:00
PMCR- 2020/03/28
CRDT- 2018/03/26 06:00
PHST- 2017/11/13 00:00 [received]
PHST- 2018/03/20 00:00 [accepted]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2018/11/15 06:00 [medline]
PHST- 2018/03/26 06:00 [entrez]
PHST- 2020/03/28 00:00 [pmc-release]
AID - 10.1007/s10047-018-1036-3 [pii]
AID - 1036 [pii]
AID - 10.1007/s10047-018-1036-3 [doi]
PST - ppublish
SO  - J Artif Organs. 2018 Sep;21(3):371-373. doi: 10.1007/s10047-018-1036-3. Epub 2018 
      Mar 24.