PMID- 29575722
OWN - NLM
STAT- MEDLINE
DCOM- 20181108
LR  - 20181108
IS  - 1932-846X (Electronic)
IS  - 1932-8451 (Linking)
VI  - 78
IP  - 7
DP  - 2018 Jul
TI  - Differential effects of transient and sustained activation of BDNF-TrkB 
      signaling.
PG  - 647-659
LID - 10.1002/dneu.22592 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) serves a pleiotropic role in the central 
      nervous system, ranging from promoting neuronal survival and differentiation 
      during development and synaptic modulation in the adult. An important, yet 
      unanswered question is how BDNF could serve such diverse functions, sometimes in 
      the same cell. At least two modes of BDNF actions have been elucidated so far 
      based on BDNF signaling kinetics and/or the activity status of the responding 
      neurons. Acute and gradual increases in extracellular BDNF concentrations elicit, 
      respectively, transient and sustained activation of TrkB receptor and its 
      downstream signaling, leading to differential molecular and cellular functions. 
      In cultured neurons, sustained TrkB activation promotes neuronal dendritic 
      arborization and spinogenesis, whereas transient TrkB activation facilitates 
      dendritic growth and spine morphogenesis. In hippocampal slices, slow delivery of 
      BDNF facilitates LTP, whereas fast application of BDNF enhances basal synaptic 
      transmission in schaffer collateral synapses. High-frequency stimulation of 
      neurons converts BDNF-induced TrkB signaling from a transient to a sustained 
      mode. These initial insights lay the foundation for future investigation of the 
      BDNF-TrkB pathway, and analogous signaling pathways to gain a comprehensive 
      understanding to enable translational research. (c) 2018 Wiley Periodicals, Inc. 
      Develop Neurobiol 78: 647-659, 2018.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Guo, Wei
AU  - Guo W
AD  - School of Pharmaceutical Sciences, IDG/McGovern Institute for Brain Research, 
      Tsinghua University, Beijing, 100084, China.
AD  - R&D Center for the Diagnosis and Treatment of Major Brain Diseases, Research 
      Institute of Tsinghua University in Shenzhen, Shenzhen, Guandong, 518057, China.
FAU - Nagappan, Guhan
AU  - Nagappan G
AD  - GlaxoSmithKline, R&D China, Shanghai, 201203, China.
FAU - Lu, Bai
AU  - Lu B
AUID- ORCID: 0000-0002-9763-6616
AD  - School of Pharmaceutical Sciences, IDG/McGovern Institute for Brain Research, 
      Tsinghua University, Beijing, 100084, China.
AD  - R&D Center for the Diagnosis and Treatment of Major Brain Diseases, Research 
      Institute of Tsinghua University in Shenzhen, Shenzhen, Guandong, 518057, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180331
PL  - United States
TA  - Dev Neurobiol
JT  - Developmental neurobiology
JID - 101300215
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Neurons/metabolism
MH  - Receptor, trkB/*metabolism
MH  - Signal Transduction
MH  - Time Factors
OTO - NOTNLM
OT  - acute and chronic
OT  - neuronal activity
OT  - neurotrophin
OT  - signaling kinetics
OT  - transient and sustained
EDAT- 2018/03/27 06:00
MHDA- 2018/11/09 06:00
CRDT- 2018/03/26 06:00
PHST- 2017/12/13 00:00 [received]
PHST- 2018/03/20 00:00 [accepted]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2018/11/09 06:00 [medline]
PHST- 2018/03/26 06:00 [entrez]
AID - 10.1002/dneu.22592 [doi]
PST - ppublish
SO  - Dev Neurobiol. 2018 Jul;78(7):647-659. doi: 10.1002/dneu.22592. Epub 2018 Mar 31.