PMID- 29575913
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20180515
IS  - 0236-5383 (Print)
IS  - 0236-5383 (Linking)
VI  - 69
IP  - 1
DP  - 2018 Mar
TI  - Age-related and function-dependent regional alterations of free L- and 
      D-aspartate in postembryonic chick brain.
PG  - 1-15
LID - 10.1556/018.68.2018.1.1 [doi]
AB  - D-aspartate (D-Asp) modulates adult neural plasticity and embryonic brain 
      development by promoting cell proliferation, survival and differentiation. Here, 
      developmental changes of the excitatory amino acids (EAAs) L-Glu, L-Asp and D-Asp 
      were determined during the first postembryonic days, a time window for early 
      learning, in selected brain regions of domestic chickens after chiral separation 
      and capillary electrophoresis. Extracellular concentration (ECC) of EAAs was 
      measured in microdialysis samples from freely moving chicks. ECC of D-Asp (but 
      not L-EAAs) decreased during the first week of age, with no considerable regional 
      or learning-related variation. ECC of L-Asp and L-Glu (but not of D-Asp) were 
      elevated in the mSt/Ac in response to a rewarding stimulus, suggesting importance 
      of Asp-Glu co-release in synaptic plasticity of basal ganglia. Potassium-evoked 
      release of D-Asp, with a protracted transient, was also demonstrated. D-Asp 
      constitutes greater percentage of total aspartate in the extracellular space than 
      in whole tissue extracts, thus the bulk of D-Asp detected in tissue appears in 
      the extracellular space. Conversely, only a fraction of tissue L-EAAs can be 
      detected in extracellular space. The lack of changes in tissue D-Asp following 
      avoidance learning indicates a tonic, rather than phasic, mechanism in the 
      neuromodulatory action of this amino acid.
FAU - Zachar, Gergely
AU  - Zachar G
AD  - 1 Department of Anatomy, Histology and Embryology Semmelweis University , Tuzolto 
      u. 58, H-1094 Budapest , Hungary.
FAU - Jako, Tamas
AU  - Jako T
AD  - 2 Department of Pharmacodynamics Semmelweis University , Budapest , Hungary.
FAU - Vincze, Istvan
AU  - Vincze I
AD  - 2 Department of Pharmacodynamics Semmelweis University , Budapest , Hungary.
FAU - Wagner, Zsolt
AU  - Wagner Z
AD  - 2 Department of Pharmacodynamics Semmelweis University , Budapest , Hungary.
FAU - Tabi, Tamas
AU  - Tabi T
AD  - 2 Department of Pharmacodynamics Semmelweis University , Budapest , Hungary.
FAU - Balint, Eszter
AU  - Balint E
AD  - 1 Department of Anatomy, Histology and Embryology Semmelweis University , Tuzolto 
      u. 58, H-1094 Budapest , Hungary.
FAU - Mezey, Szilvia
AU  - Mezey S
AD  - 1 Department of Anatomy, Histology and Embryology Semmelweis University , Tuzolto 
      u. 58, H-1094 Budapest , Hungary.
FAU - Szoko, Eva
AU  - Szoko E
AD  - 2 Department of Pharmacodynamics Semmelweis University , Budapest , Hungary.
FAU - Csillag, Andras
AU  - Csillag A
AD  - 1 Department of Anatomy, Histology and Embryology Semmelweis University , Tuzolto 
      u. 58, H-1094 Budapest , Hungary.
LA  - eng
PT  - Journal Article
PL  - Hungary
TA  - Acta Biol Hung
JT  - Acta biologica Hungarica
JID - 8404358
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 4SR0Q8YD1X (D-Aspartic Acid)
RN  - IY9XDZ35W2 (Glucose)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Aspartic Acid/*metabolism
MH  - Avoidance Learning/*physiology
MH  - Brain/embryology/growth & development/*metabolism
MH  - Chick Embryo
MH  - Chickens
MH  - D-Aspartic Acid/*metabolism
MH  - Extracellular Space/drug effects/metabolism
MH  - Glucose/metabolism
MH  - Memory/physiology
MH  - Microdialysis
MH  - Potassium/pharmacology
MH  - Time Factors
OTO - NOTNLM
OT  - D-aspartic acid
OT  - amygdala
OT  - arcopallium
OT  - avian brain
OT  - postembryonic development
EDAT- 2018/03/27 06:00
MHDA- 2018/05/16 06:00
CRDT- 2018/03/27 06:00
PHST- 2018/03/27 06:00 [entrez]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
AID - 10.1556/018.68.2018.1.1 [doi]
PST - ppublish
SO  - Acta Biol Hung. 2018 Mar;69(1):1-15. doi: 10.1556/018.68.2018.1.1.