PMID- 2957600
OWN - NLM
STAT- MEDLINE
DCOM- 19870930
LR  - 20190725
IS  - 0028-1298 (Print)
IS  - 0028-1298 (Linking)
VI  - 335
IP  - 6
DP  - 1987 Jun
TI  - Relation between yawning behavior and central serotonergic neuronal system in 
      rats.
PG  - 667-72
AB  - Subcutaneously (s.c.) administered apomorphine (0.0125-0.4 mg/kg) or 
      physostigmine (0.025-0.4 mg/kg) to rats elicited yawning. The dose-response 
      curves were bell-shaped. The peak effects of apomorphine and physostigmine were 
      observed with a dose of 0.1 mg/kg of each drug. Yawning elicited by apomorphine 
      (0.1 mg/kg) or physostigmine (0.1 mg/kg) was reduced by intraperitoneally (i.p.) 
      administered 5-hydroxytryptophan (5-HTP, 50-200 mg/kg, given 30 min before). 
      Yawning elicited by apomorphine but not by physostigmine was enhanced by 
      p-chlorophenylalanine (p-CPA, 25-400 mg/kg i.p., given 24 h before). Apomorphine 
      elicited but not physostigmine-elicited yawning was enhanced by pretreatment with 
      5,7-dihydroxytryptamine (5,7-DHT, 8 micrograms/rat, given 14 days before into the 
      dorsal raphe). This treatment led to a 35% depletion of serotonin (5-HT) in the 
      striatum. 5-HTP, p-CPA or 5,7-DHT given alone did not elicit yawning. Bilateral, 
      intrastriatal microinjection of apomorphine (1.5-50 micrograms/site) but not 
      physostigmine (5-50 micrograms/site) elicited yawning. The dose-response curve 
      was also bell-shaped. These results indicate that central serotonergic pathways 
      play an important role in modulating drug-elicited yawning in rats.
FAU - Okuyama, S
AU  - Okuyama S
FAU - Shimamura, H
AU  - Shimamura H
FAU - Hashimoto, S
AU  - Hashimoto S
FAU - Aihara, H
AU  - Aihara H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Naunyn Schmiedebergs Arch Pharmacol
JT  - Naunyn-Schmiedeberg's archives of pharmacology
JID - 0326264
RN  - 31363-74-3 (5,7-Dihydroxytryptamine)
RN  - 333DO1RDJY (Serotonin)
RN  - 9U1VM840SP (Physostigmine)
RN  - C1LJO185Q9 (5-Hydroxytryptophan)
RN  - N21FAR7B4S (Apomorphine)
RN  - R5J7E3L9SP (Fenclonine)
SB  - IM
MH  - 5,7-Dihydroxytryptamine/pharmacology
MH  - 5-Hydroxytryptophan/pharmacology
MH  - Animals
MH  - Apomorphine/administration & dosage/pharmacology
MH  - Corpus Striatum/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Fenclonine/pharmacology
MH  - Male
MH  - Microinjections
MH  - Physostigmine/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*physiology
MH  - Yawning/*drug effects
EDAT- 1987/06/01 00:00
MHDA- 1987/06/01 00:01
CRDT- 1987/06/01 00:00
PHST- 1987/06/01 00:00 [pubmed]
PHST- 1987/06/01 00:01 [medline]
PHST- 1987/06/01 00:00 [entrez]
AID - 10.1007/BF00166984 [doi]
PST - ppublish
SO  - Naunyn Schmiedebergs Arch Pharmacol. 1987 Jun;335(6):667-72. doi: 
      10.1007/BF00166984.