PMID- 29576121
OWN - NLM
STAT- MEDLINE
DCOM- 20190104
LR  - 20190104
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 120
IP  - 4
DP  - 2018 Apr
TI  - Anti-nociceptive effects of caloric restriction on neuropathic pain in rats 
      involves silent information regulator 1.
PG  - 807-817
LID - S0007-0912(17)54063-5 [pii]
LID - 10.1016/j.bja.2017.09.009 [doi]
AB  - BACKGROUND: Caloric restriction (CR) increases both average and maximum lifespan, 
      retards physiological signs of ageing, and delays the onset of several diseases 
      and may mediate neuropathic pain. Neuropathic pain seriously affects the quality 
      of life of patients. In this study, we investigated whether CR exerts 
      anti-nociceptive effects on neuropathic pain, and probed its potential 
      mechanisms. METHODS: Adult rats were divided into two dietary groups: an ad 
      libitum (AL)-fed group and a CR group, which was provided with 60% of the food 
      intake of AL rats for 6 weeks. The effects of 6-week CR on pain behaviour and 
      neuro-inflammation induced by chronic constriction injury of the sciatic nerve 
      were evaluated. RESULTS: Rats subjected to a CR diet had reduced hypersensitivity 
      to mechanical and thermal stimuli after nerve-constriction injury. CR increased 
      the silent information regulator 1 (SIRT1) expression, and suppressed the 
      nerve-constriction-induced production of mitochondrial-derived reactive oxygen 
      species and activation of nuclear factor kappa B accompanied by suppression of 
      mature interleukin-1beta production in the ipsilateral spinal cord dorsal horn. The 
      inhibition of SIRT1 reversed the effects of caloric restriction on pain 
      behaviours. Moreover, CR decreased the phosphorylation of N-methyl-d-aspartate 
      receptor subunits and the mitogen-activated protein kinase family, decreased the 
      sensory neurone excitability, and inhibited the nerve-constriction-induced 
      glial-cell activation. CONCLUSIONS: These results suggest that the effects of CR 
      on pain behaviours in a rat model of nerve injury are via inhibition of excessive 
      neuro-inflammation induced by the injury. CR may be of benefit in patients with 
      neuropathic pain.
CI  - Copyright (c) 2017 British Journal of Anaesthesia. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Liu, Y
AU  - Liu Y
AD  - Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical School 
      of Nanjing University, Nanjing, Jiangsu Province, China.
FAU - Ni, Y
AU  - Ni Y
AD  - Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical School 
      of Nanjing University, Nanjing, Jiangsu Province, China.
FAU - Zhang, W
AU  - Zhang W
AD  - Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical School 
      of Nanjing University, Nanjing, Jiangsu Province, China.
FAU - Sun, Y E
AU  - Sun YE
AD  - Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical School 
      of Nanjing University, Nanjing, Jiangsu Province, China.
FAU - Jiang, M
AU  - Jiang M
AD  - Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical School 
      of Nanjing University, Nanjing, Jiangsu Province, China.
FAU - Gu, W J
AU  - Gu WJ
AD  - Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical School 
      of Nanjing University, Nanjing, Jiangsu Province, China.
FAU - Ma, Z L
AU  - Ma ZL
AD  - Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical School 
      of Nanjing University, Nanjing, Jiangsu Province, China. Electronic address: 
      mazhengliang1964@nju.edu.cn.
FAU - Gu, X P
AU  - Gu XP
AD  - Department of Anaesthesiology, Affiliated Drum Tower Hospital of Medical School 
      of Nanjing University, Nanjing, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
DEP - 20180117
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Inflammation/genetics/physiopathology/prevention & control
MH  - Male
MH  - Neuralgia/*genetics/*prevention & control
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sciatic Nerve/physiopathology
MH  - Sirtuin 1/*genetics
OTO - NOTNLM
OT  - SIRT1 protein
OT  - caloric restriction
OT  - neuropathic pain
EDAT- 2018/03/27 06:00
MHDA- 2019/01/05 06:00
CRDT- 2018/03/27 06:00
PHST- 2016/11/30 00:00 [received]
PHST- 2017/09/24 00:00 [revised]
PHST- 2017/09/25 00:00 [accepted]
PHST- 2018/03/27 06:00 [entrez]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2019/01/05 06:00 [medline]
AID - S0007-0912(17)54063-5 [pii]
AID - 10.1016/j.bja.2017.09.009 [doi]
PST - ppublish
SO  - Br J Anaesth. 2018 Apr;120(4):807-817. doi: 10.1016/j.bja.2017.09.009. Epub 2018 
      Jan 17.