PMID- 29576798
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2018
DP  - 2018
TI  - Jinkui Shenqi Pills Ameliorate Asthma with "Kidney Yang Deficiency" by Enhancing 
      the Function of the Hypothalamic-Pituitary-Adrenal Axis to Regulate T Helper 1/2 
      Imbalance.
PG  - 7253240
LID - 10.1155/2018/7253240 [doi]
LID - 7253240
AB  - The aim of the study was to investigate the effects and underlying mechanism of 
      JKSQP in a rat model of asthma with kidney-yang deficiency (KYD). Materials and 
      Methods. Hydrocortisone (HYD) was used to establish the rat model of KYD; rats 
      were then sensitized and challenged with ovalbumin (OVA). JKSQP was administered 
      to OVA-challenged rats, and the changes in signs and symptoms of KYD were 
      observed. The leukocyte number and subpopulations in bronchoalveolar lavage fluid 
      (BALF) were counted and the cells were stained with Wright-Giemsa dye. Serum 
      adrenocorticotropic hormone (ACTH), corticosterone (CORT), 
      corticotropin-releasing hormone (CRH), total immunoglobulin E (IgE), and 
      OVA-specific IgE levels were determined using relevant enzyme-linked 
      immunosorbent assays (ELISA) kits. Results. JKSQP not only reversed the 
      phenomenon of KYD but also significantly inhibited the number of leukocyte and 
      eosinophils in the BALF, increasing the level of interferon (IFN)-gamma and 
      decreasing the levels of interleukin-4 (IL-4) and IgE in the serum compared with 
      the OVA-challenged groups. Conclusions. Taken together, the antiasthma effects of 
      JKSQP were likely mediated by the enhancement of the function of the 
      hypothalamic-pituitary-adrenal axis and the reversal of T helper 1/2 imbalance.
FAU - Ji, Bing
AU  - Ji B
AD  - Huzhou Hospital of Traditional Chinese Medicine, Affiliated Zhejiang Chinese 
      Medical University, HuZhou 313003, China.
FAU - Li, Yuan-Yuan
AU  - Li YY
AD  - Institute of Comparative Medicine & Experimental Animal Research Center, Zhejiang 
      Chinese Medical University, Hangzhou 310005, China.
FAU - Yang, Wei-Ji
AU  - Yang WJ
AD  - Graduate School, Zhejiang Chinese Medical University, Hangzhou 310053, China.
FAU - Zhang, Li-Zong
AU  - Zhang LZ
AD  - Institute of Comparative Medicine & Experimental Animal Research Center, Zhejiang 
      Chinese Medical University, Hangzhou 310005, China.
FAU - Fang, Ming-Sun
AU  - Fang MS
AD  - Institute of Comparative Medicine & Experimental Animal Research Center, Zhejiang 
      Chinese Medical University, Hangzhou 310005, China.
FAU - Fu, Hui-Ying
AU  - Fu HY
AUID- ORCID: 0000-0002-1782-5258
AD  - Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 
      310005, China.
FAU - Shou, Qi-Yang
AU  - Shou QY
AUID- ORCID: 0000-0003-1615-5309
AD  - Institute of Comparative Medicine & Experimental Animal Research Center, Zhejiang 
      Chinese Medical University, Hangzhou 310005, China.
LA  - eng
PT  - Journal Article
DEP - 20180208
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5822917
EDAT- 2018/03/27 06:00
MHDA- 2018/03/27 06:01
PMCR- 2018/02/08
CRDT- 2018/03/27 06:00
PHST- 2017/07/31 00:00 [received]
PHST- 2017/11/15 00:00 [revised]
PHST- 2017/12/20 00:00 [accepted]
PHST- 2018/03/27 06:00 [entrez]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2018/03/27 06:01 [medline]
PHST- 2018/02/08 00:00 [pmc-release]
AID - 10.1155/2018/7253240 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2018 Feb 8;2018:7253240. doi: 
      10.1155/2018/7253240. eCollection 2018.