PMID- 29578117 OWN - NLM STAT- MEDLINE DCOM- 20180904 LR - 20220316 IS - 2542-5641 (Electronic) IS - 0366-6999 (Print) IS - 0366-6999 (Linking) VI - 131 IP - 7 DP - 2018 Apr 5 TI - Platelet Distribution Width on Admission Predicts In-Stent Restenosis in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus Treated with Percutaneous Coronary Intervention. PG - 757-763 LID - 10.4103/0366-6999.228247 [doi] AB - BACKGROUND: It is known that there is a definite association between platelet distribution width (PDW) and poor prognosis in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). However, there are no data available regarding the prognostic significance of PDW for in-stent restenosis (ISR) in patients with CAD and T2DM. We aimed to determine the value of PDW on admission that predicted ISR in patients with CAD and T2DM. METHODS: Between January 2012 and December 2013, a total of 5232 consecutive patients diagnosed with CAD and T2DM undergoing percutaneous coronary intervention were admitted. Three years of retrospective follow-up was undertaken. A total of 438 patients with second angiography operations were included. ISR was defined as >/=50% luminal stenosis of the stent or peri-stent segments. Continuous data were presented as the mean +/- standard deviation or median (P(25), P(75)) and were compared by one-way analysis of variance or Kruskal-Wallis H-test. Categorical variables were presented as percentages and were compared by Chi-square test or Fisher's exact test. The association between PDW and ISR was calculated by logistic regression analysis. A two-sided value of P < 0.05 was considered statistically significant. Statistical analyses were performed by SPSS version 22.0 for windows. RESULTS: Fifty-nine patients with ISR, accounting for 13.5% of the total, were included. ISR was significantly more frequent in patients with higher PDW quartiles compared with lower quartiles. We observed that PDW had a strong relationship with mean platelet volume (r = 0.647, 95% confidence interval [CI]: 0.535-0.750, P < 0.0001). The receiver-operating characteristic curves showed that the PDW cutoff value for predicting ISR rate was 13.65 fl with sensitivity of 59.3% and specificity of 72.4% (area under curve [AUC] = 0.701, 95% CI: 0.625-0.777, P < 0.001). Multivariate analysis showed that the risk of ISR increased approximately 30% when PDW increased one unit (odds ratio [OR]: 1.289, 95% CI: 1.110-1.498, P = 0.001). Patients with higher PDW, defined as more than 13.65 fl, had a 4-fold higher risk of ISR compared with lower PDW (OR: 4.241, 95% CI: 1.879-9.572, P = 0.001). Furthermore, when patients were divided by PDW quartiles values, PDW was able to predict ISR (Q2: OR = 0.762, 95% CI: 0.189-3.062, P = 0.762; Q3: OR = 2.782, 95% CI: 0.865-8.954, P = 0.086; and Q4: OR = 3.849, 95% CI: 1.225-12.097, P = 0.021, respectively; P for trend <0.0001). CONCLUSION: PDW is an independent predictor of ISR in patients with CAD and T2DM. FAU - Hu, Cheng-Ping AU - Hu CP AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing 100029, China. FAU - Du, Yu AU - Du Y AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing 100029, China. FAU - Zhu, Yong AU - Zhu Y AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing 100029, China. FAU - Shi, Chao AU - Shi C AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing 100029, China. FAU - Qin, Zheng AU - Qin Z AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing 100029, China. FAU - Zhao, Ying-Xin AU - Zhao YX AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing 100029, China. LA - eng PT - Journal Article PL - China TA - Chin Med J (Engl) JT - Chinese medical journal JID - 7513795 SB - IM MH - Adult MH - Aged MH - Blood Platelets/*metabolism MH - Coronary Artery Disease/*metabolism/therapy MH - Coronary Restenosis/*metabolism/therapy MH - Diabetes Mellitus, Type 2/*metabolism/therapy MH - Female MH - Humans MH - Male MH - Mean Platelet Volume MH - Middle Aged MH - Percutaneous Coronary Intervention MH - Retrospective Studies PMC - PMC5887732 OTO - NOTNLM OT - Blood Platelet OT - Coronary Restenosis OT - Mean Platelet Volume OT - Percutaneous Coronary Intervention COIS- There are no conflicts of interest EDAT- 2018/03/27 06:00 MHDA- 2018/09/05 06:00 PMCR- 2018/04/05 CRDT- 2018/03/27 06:00 PHST- 2018/03/27 06:00 [entrez] PHST- 2018/03/27 06:00 [pubmed] PHST- 2018/09/05 06:00 [medline] PHST- 2018/04/05 00:00 [pmc-release] AID - ChinMedJ_2018_131_7_757_228247 [pii] AID - CMJ-131-757 [pii] AID - 10.4103/0366-6999.228247 [doi] PST - ppublish SO - Chin Med J (Engl). 2018 Apr 5;131(7):757-763. doi: 10.4103/0366-6999.228247.