PMID- 29578221
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190111
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 10
IP  - 14
DP  - 2018 Apr 5
TI  - Packing of metalized polymer nanofibers for aneurysm embolization.
PG  - 6589-6601
LID - 10.1039/c7nr09645c [doi]
AB  - Aneurysmal subarachnoid hemorrhage (SAH) is the extravasation of blood into the 
      subarachnoid space and is fatal in most cases. Platinum coils have been used to 
      fill the hemorrhage site and prevent the extravasation of blood. Here we explored 
      the use of Pt-coated polymer nanofibers (NF) to prevent blood extravasation and 
      were able to achieve improved results in vitro. The polymer nanofibers were 
      produced via electrospinning and were subsequently electroplated with Pt, 
      resulting in metalized nanofibers. These nanofibers were installed within a 
      microfluidic channel, and the resulting reduction in the permeability was 
      evaluated using a fluid similar to blood. Based on the obtained results, these 
      newly developed nanofibers are expected to decrease the operation cost for SAH, 
      owing to their reduced size and low material cost. Furthermore, it is expected 
      that these nanofibers will be used in a smaller amount during SAH operation while 
      having the same preventive effect. This should reduce the operational risk 
      associated with the multiple steps required to place the Pt coils at the SAH 
      site. Finally, the underlying hydrodynamic mechanism responsible for the reduced 
      permeability of the synthesized nanofibers is described.
FAU - Kim, Min-Woo
AU  - Kim MW
AD  - School of Mechanical Engineering, Korea University, Seoul 02841, Republic of 
      Korea. skyoon@korea.ac.kr.
FAU - An, Seongpil
AU  - An S
FAU - Kim, Karam
AU  - Kim K
FAU - Kim, Tae-Gun
AU  - Kim TG
FAU - Jo, Hong Seok
AU  - Jo HS
FAU - Park, Dong-Hyuk
AU  - Park DH
FAU - Yoon, Sam S
AU  - Yoon SS
FAU - Yarin, Alexander L
AU  - Yarin AL
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Polymers)
SB  - IM
MH  - Aneurysm/*therapy
MH  - *Embolization, Therapeutic
MH  - Humans
MH  - Nanofibers/*chemistry
MH  - Polymers/chemistry
MH  - Subarachnoid Hemorrhage/*therapy
EDAT- 2018/03/27 06:00
MHDA- 2019/01/12 06:00
CRDT- 2018/03/27 06:00
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/03/27 06:00 [entrez]
AID - 10.1039/c7nr09645c [doi]
PST - ppublish
SO  - Nanoscale. 2018 Apr 5;10(14):6589-6601. doi: 10.1039/c7nr09645c.