PMID- 29579370
OWN - NLM
STAT- MEDLINE
DCOM- 20190722
LR  - 20190802
IS  - 2326-5205 (Electronic)
IS  - 2326-5191 (Print)
IS  - 2326-5191 (Linking)
VI  - 70
IP  - 8
DP  - 2018 Aug
TI  - Encoding of Self-Referential Pain Catastrophizing in the Posterior Cingulate 
      Cortex in Fibromyalgia.
PG  - 1308-1318
LID - 10.1002/art.40507 [doi]
AB  - OBJECTIVE: Pain catastrophizing is a common feature of chronic pain, including 
      fibromyalgia (FM), and is strongly associated with amplified pain severity and 
      disability. While previous neuroimaging studies have focused on evoked pain 
      response modulation by catastrophizing, the brain mechanisms supporting pain 
      catastrophizing itself are unknown. We designed a functional magnetic resonance 
      imaging (fMRI)-based pain catastrophizing task whereby patients with chronic pain 
      engaged in catastrophizing-related cognitions. We undertook this study to test 
      our hypothesis that catastrophizing about clinical pain would be associated with 
      amplified activation in nodes of the default mode network (DMN), which encode 
      self-referential cognition and show altered functioning in chronic pain. METHODS: 
      During fMRI, 31 FM patients reflected on how catastrophizing (CAT) statements 
      (drawn from the Pain Catastrophizing Scale) impact their typical FM pain 
      experience. Response to CAT statements was compared to response to matched 
      neutral (NEU) statements. RESULTS: During statement reflection, higher fMRI 
      signal during CAT statements than during NEU statements was found in several DMN 
      brain areas, including the ventral (posterior) and dorsal (anterior) posterior 
      cingulate cortex (vPCC and dPCC, respectively). Patients' ratings of CAT 
      statement applicability were correlated solely with activity in the vPCC, a main 
      DMN hub supporting self-referential cognition (r = 0.38, P < 0.05). Clinical pain 
      severity was correlated solely with activity in the dPCC, a PCC subregion 
      associated with cognitive control and sensorimotor processing (r = 0.38, P < 
      0.05). CONCLUSION: These findings provide evidence that the PCC encodes pain 
      catastrophizing in FM and suggest distinct roles for different PCC subregions. 
      Understanding the brain circuitry encoding pain catastrophizing in FM will prove 
      to be important in identifying and evaluating the success of interventions 
      targeting negative affect in chronic pain management.
CI  - (c) 2018, American College of Rheumatology.
FAU - Lee, Jeungchan
AU  - Lee J
AUID- ORCID: 0000-0002-4424-175X
AD  - Massachusetts General Hospital, Boston.
FAU - Protsenko, Ekaterina
AU  - Protsenko E
AD  - Massachusetts General Hospital, Boston.
FAU - Lazaridou, Asimina
AU  - Lazaridou A
AD  - Harvard Medical School, Brigham and Women's Hospital, and Massachusetts General 
      Hospital, Boston.
FAU - Franceschelli, Olivia
AU  - Franceschelli O
AD  - Harvard Medical School, Brigham and Women's Hospital, and Massachusetts General 
      Hospital, Boston.
FAU - Ellingsen, Dan-Mikael
AU  - Ellingsen DM
AD  - Massachusetts General Hospital, Boston.
FAU - Mawla, Ishtiaq
AU  - Mawla I
AD  - Massachusetts General Hospital, Boston.
FAU - Isenburg, Kylie
AU  - Isenburg K
AD  - Massachusetts General Hospital, Boston.
FAU - Berry, Michael P
AU  - Berry MP
AD  - Massachusetts General Hospital, Boston.
FAU - Galenkamp, Laura
AU  - Galenkamp L
AD  - Harvard Medical School, Brigham and Women's Hospital, and Massachusetts General 
      Hospital, Boston.
FAU - Loggia, Marco L
AU  - Loggia ML
AD  - Massachusetts General Hospital, Boston.
FAU - Wasan, Ajay D
AU  - Wasan AD
AD  - University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, and 
      Massachusetts General Hospital, Boston.
FAU - Edwards, Robert R
AU  - Edwards RR
AD  - Harvard Medical School, Brigham and Women's Hospital, and Massachusetts General 
      Hospital, Boston.
FAU - Napadow, Vitaly
AU  - Napadow V
AD  - Massachusetts General Hospital, Boston.
LA  - eng
SI  - ClinicalTrials.gov/NCT01345344
GR  - R01 AR064367/AR/NIAMS NIH HHS/United States
GR  - S10 RR021110/RR/NCRR NIH HHS/United States
GR  - P41 RR014075/RR/NCRR NIH HHS/United States
GR  - R01 AT007550/AT/NCCIH NIH HHS/United States
GR  - P01 AT006663/AT/NCCIH NIH HHS/United States
GR  - S10 RR023043/RR/NCRR NIH HHS/United States
GR  - R61 AT009306/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180622
PL  - United States
TA  - Arthritis Rheumatol
JT  - Arthritis & rheumatology (Hoboken, N.J.)
JID - 101623795
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Catastrophization/*diagnostic imaging/psychology
MH  - Chronic Pain/*diagnostic imaging/psychology
MH  - Cognition
MH  - Female
MH  - Fibromyalgia/*diagnostic imaging/psychology
MH  - Gyrus Cinguli/*diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Young Adult
PMC - PMC6105462
MID - NIHMS954394
COIS- Authors do not have any conflict of interest with regard to the work.
EDAT- 2018/03/27 06:00
MHDA- 2019/07/23 06:00
PMCR- 2019/08/01
CRDT- 2018/03/27 06:00
PHST- 2017/11/03 00:00 [received]
PHST- 2018/03/20 00:00 [accepted]
PHST- 2018/03/27 06:00 [pubmed]
PHST- 2019/07/23 06:00 [medline]
PHST- 2018/03/27 06:00 [entrez]
PHST- 2019/08/01 00:00 [pmc-release]
AID - 10.1002/art.40507 [doi]
PST - ppublish
SO  - Arthritis Rheumatol. 2018 Aug;70(8):1308-1318. doi: 10.1002/art.40507. Epub 2018 
      Jun 22.