PMID- 29580976
OWN - NLM
STAT- MEDLINE
DCOM- 20190701
LR  - 20220331
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 190
DP  - 2018 Jun
TI  - Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in 
      Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes.
PG  - 69-77
LID - S0002-9394(18)30127-2 [pii]
LID - 10.1016/j.ajo.2018.03.026 [doi]
AB  - PURPOSE: To investigate inter-eye retinal vessel density asymmetry in healthy, 
      glaucoma suspect, and mild-to-moderate glaucoma subjects, and its potential 
      utility for early detection of glaucomatous damage. DESIGN: Cross-sectional 
      study. METHODS: In 153 subjects including 55 healthy, 32 glaucoma suspect, and 66 
      glaucoma subjects enrolled in the Diagnostic Innovations in Glaucoma Study 
      (DIGS), vessel density was obtained from optical coherence tomography angiography 
      (OCT-A) macular and optic nerve head scans. Thickness of peripapillary retinal 
      nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) was measured 
      with spectral-domain optical coherence tomography (SD-OCT) scans. Inter-eye 
      asymmetry was calculated by taking the absolute value of difference in vessel 
      density and thickness between the right and left eyes. RESULTS: Inter-eye retinal 
      vessel density asymmetry parameters were significantly different among the 3 
      groups. Glaucoma suspects had significantly higher peripapillary and macular 
      inter-eye vessel density asymmetries compared to healthy groups in univariate 
      (1.1% vs 2.0%, P = .014 and 1.2% vs 2.5%, P = .027, respectively) and 
      multivariate analyses (P = .007 and P = .038, respectively). No significant 
      differences in asymmetry of thickness parameters were found between glaucoma 
      suspect and healthy groups (all P > .718). However, significant differences in 
      asymmetry of thickness parameters between glaucoma suspects and glaucoma patients 
      (P < .01) were found for all parameters. CONCLUSION: Inter-eye vessel density 
      asymmetry can be quantified by OCT-A measurement. Glaucoma suspects have 
      significantly greater vessel density asymmetry than healthy eyes. Longitudinal 
      studies are needed to better characterize the relationship of vessel density 
      asymmetry with the development and progression of glaucoma.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Hou, Huiyuan
AU  - Hou H
AD  - Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, 
      University of California, San Diego, California, USA.
FAU - Moghimi, Sasan
AU  - Moghimi S
AD  - Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, 
      University of California, San Diego, California, USA; Department of 
      Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Zangwill, Linda M
AU  - Zangwill LM
AD  - Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, 
      University of California, San Diego, California, USA.
FAU - Shoji, Takuhei
AU  - Shoji T
AD  - Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, 
      University of California, San Diego, California, USA; Department of 
      Ophthalmology, Saitama Medical University. Iruma, Saitama, Japan.
FAU - Ghahari, Elham
AU  - Ghahari E
AD  - Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, 
      University of California, San Diego, California, USA.
FAU - Manalastas, Patricia Isabel C
AU  - Manalastas PIC
AD  - Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, 
      University of California, San Diego, California, USA.
FAU - Penteado, Rafaella C
AU  - Penteado RC
AD  - Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, 
      University of California, San Diego, California, USA.
FAU - Weinreb, Robert N
AU  - Weinreb RN
AD  - Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, 
      University of California, San Diego, California, USA. Electronic address: 
      rweinreb@ucsd.edu.
LA  - eng
GR  - R01 EY011008/EY/NEI NIH HHS/United States
GR  - R01 EY029058/EY/NEI NIH HHS/United States
GR  - P30 EY022589/EY/NEI NIH HHS/United States
GR  - R01 EY019869/EY/NEI NIH HHS/United States
GR  - R01 EY027510/EY/NEI NIH HHS/United States
GR  - U10 EY014267/EY/NEI NIH HHS/United States
GR  - R01 EY026574/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180324
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Gonioscopy
MH  - Healthy Volunteers
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Ocular Hypertension/diagnosis/physiopathology
MH  - Optic Disk/pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retinal Vessels/diagnostic imaging/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields/physiology
PMC - PMC5970064
MID - NIHMS954445
EDAT- 2018/03/28 06:00
MHDA- 2019/07/02 06:00
PMCR- 2019/06/01
CRDT- 2018/03/28 06:00
PHST- 2017/12/15 00:00 [received]
PHST- 2018/03/12 00:00 [revised]
PHST- 2018/03/14 00:00 [accepted]
PHST- 2018/03/28 06:00 [pubmed]
PHST- 2019/07/02 06:00 [medline]
PHST- 2018/03/28 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - S0002-9394(18)30127-2 [pii]
AID - 10.1016/j.ajo.2018.03.026 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2018 Jun;190:69-77. doi: 10.1016/j.ajo.2018.03.026. Epub 2018 
      Mar 24.