PMID- 29582598
OWN - NLM
STAT- MEDLINE
DCOM- 20181004
LR  - 20181004
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 36
IP  - 2
DP  - 2018 Feb 8
TI  - [Rapid screening of 24 tranquillizer drugs in fish and fishery products by 
      ultra-high performance liquid chromatography-quadrupole/electrostatic field 
      orbitrap high resolution mass spectroscopy].
PG  - 125-135
LID - 10.3724/SP.J.1123.2017.10002 [doi]
AB  - A method was developed for the simultaneous determination of 24 tranquillizer 
      drugs in fish and fishery products using ultra-high performance liquid 
      chromatography-quadrupole/electrostatic field orbitrap high resolution mass 
      spectrometry (UPLC-Q-Orbitrap HRMS). The samples were extracted with 
      acetonitrile. Then, the extracts were concentrated, dissolved by 50% (v/v) 
      methanol aqueous solution, cleaned up with hexane saturated by acetonitrile. The 
      separation was performed on an ACQUITY UPLC((R)) BEH C(18) column (100 mmx2.1 mm, 
      1.7 mum) with the gradient elution using acetonitrile and water both containing 
      0.1% (v/v) formic acid as mobile phases. The drugs were analyzed by full MS 
      scan/data dependent MS(2) (Full MS/dd-MS(2))(Top 1) mode by heating electrospray 
      ion (HESI) source. The results were quantified by external standard method. The 
      calibration curves of the 24 tranquillizer drugs were linear in their respective 
      linear range, the decision coefficients (r(2)) were no less than 0.9968. The 
      average spiked recoveries of the 24 tranquillizer drugs were 58.9%-122.9%, and 
      the relative standard deviations (RSDs) were 0.1%-16.4% in the six kinds of fish 
      and fishery products at three spiked levels. The limits of quantification (LOQs) 
      of the 24 tranquillizer drugs were 0.1-5.0 mug/kg. The method is simple, rapid, 
      sensitive, reliable and suitable for the screening of the 24 tranquillizer drugs 
      in fish and fishery products.
FAU - Li, Rong
AU  - Li R
AD  - Inspection and Quarantine Technology Center, Zhongshan Entry-Exit Inspection and 
      Quarantine Bureau, Zhongshan 528400, China. lirong828@126.com.
FAU - Yang, Luqi
AU  - Yang L
AD  - Inspection and Quarantine Technology Center, Zhongshan Entry-Exit Inspection and 
      Quarantine Bureau, Zhongshan 528400, China.
AD  - School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, 
      China.
FAU - Zhang, Pengyun
AU  - Zhang P
AD  - Inspection and Quarantine Technology Center, Zhongshan Entry-Exit Inspection and 
      Quarantine Bureau, Zhongshan 528400, China.
FAU - Luo, Yangdan
AU  - Luo Y
AD  - Inspection and Quarantine Technology Center, Zhongshan Entry-Exit Inspection and 
      Quarantine Bureau, Zhongshan 528400, China.
FAU - Zhang, Pengjie
AU  - Zhang P
AD  - Inspection and Quarantine Technology Center, Zhongshan Entry-Exit Inspection and 
      Quarantine Bureau, Zhongshan 528400, China.
FAU - Gao, Yongqing
AU  - Gao Y
AD  - School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, 
      China. yongqingg@163.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
SB  - IM
MH  - Animals
MH  - *Chromatography, High Pressure Liquid
MH  - Fisheries
MH  - Fishes
MH  - *Mass Spectrometry
MH  - Seafood/*analysis
OTO - NOTNLM
OT  - fish and fishery products
OT  - quadrupole/electrostatic field orbitrap high resolution mass spectroscopy 
      (Q-Orbitrap HRMS)
OT  - tranquillizer drugs
OT  - ultra-high performance liquid chromatography (UPLC)
EDAT- 2018/03/28 06:00
MHDA- 2018/10/05 06:00
CRDT- 2018/03/28 06:00
PHST- 2018/03/28 06:00 [entrez]
PHST- 2018/03/28 06:00 [pubmed]
PHST- 2018/10/05 06:00 [medline]
AID - 10.3724/SP.J.1123.2017.10002 [doi]
PST - ppublish
SO  - Se Pu. 2018 Feb 8;36(2):125-135. doi: 10.3724/SP.J.1123.2017.10002.