PMID- 2958266
OWN - NLM
STAT- MEDLINE
DCOM- 19871119
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 99
IP  - 3
DP  - 1987 Mar
TI  - The spatial and temporal pattern of collagens I and II and keratan sulphate in 
      the developing chick metatarsophalangeal joint.
PG  - 383-91
AB  - Both intrinsic and extrinsic factors are known to be involved in the 
      morphogenesis of diarthrodial joints. The use of specific antibodies to collagens 
      I and II and keratan-sulphate-containing proteoglycans (KSPG) has enabled the 
      distributions of these macromolecules to be followed during the development of 
      the third metatarsophalangeal joint in the chicken embryo. Our study shows that 
      cartilage differentiation occurs as a continuous rod, which is then subsequently 
      divided into separate elements. Further development also reveals that, unlike the 
      matrix of the cartilaginous elements, there is a differential distribution of 
      collagen (type II) and KSPG in the presumptive joint region. It is proposed that 
      a decrease in KSPG in the presumptive joint region at stages 28/30 may be 
      involved in the mechanism for the flattening of cells in formation of the 
      interzone. Whereas, a decrease in collagen across the joint interzone region may 
      provide an area of weakness, which might allow forces produced by the developing 
      musculature to cause cavitation.
FAU - Craig, F M
AU  - Craig FM
AD  - Institute of Orthopaedics, Royal National Orthopaedic Hospital, Stanmore, 
      Middlesex, UK.
FAU - Bentley, G
AU  - Bentley G
FAU - Archer, C W
AU  - Archer CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Glycosaminoglycans)
RN  - 9007-34-5 (Collagen)
RN  - 9056-36-4 (Keratan Sulfate)
SB  - IM
MH  - Animals
MH  - Cartilage/embryology/metabolism
MH  - Chick Embryo
MH  - Collagen/*metabolism
MH  - Fluorescent Antibody Technique
MH  - Glycosaminoglycans/*metabolism
MH  - Keratan Sulfate/*metabolism
MH  - Tissue Distribution
MH  - Toe Joint/*embryology/metabolism
EDAT- 1987/03/01 00:00
MHDA- 1987/03/01 00:01
CRDT- 1987/03/01 00:00
PHST- 1987/03/01 00:00 [pubmed]
PHST- 1987/03/01 00:01 [medline]
PHST- 1987/03/01 00:00 [entrez]
AID - 10.1242/dev.99.3.383 [doi]
PST - ppublish
SO  - Development. 1987 Mar;99(3):383-91. doi: 10.1242/dev.99.3.383.