PMID- 29582716
OWN - NLM
STAT- MEDLINE
DCOM- 20190820
LR  - 20190820
IS  - 2040-1752 (Electronic)
IS  - 2040-1744 (Linking)
VI  - 9
IP  - 4
DP  - 2018 Aug
TI  - Amygdala - and serum - neurotrophic factor levels depend on rearing condition in 
      male rats.
PG  - 377-380
LID - 10.1017/S2040174418000144 [doi]
AB  - Early life experiences could determine brain and behavioral development. 
      Neurotrophic factors are likely to mediate the effects of the experience on brain 
      structures and function. Brain-derived neurotrophic factor (BDNF) plays a central 
      role in psychiatric disorders. To investigate the effects of early rearing 
      condition on the amygdala - and serum - BDNF levels, we reared male Wistar rats 
      from weaning (postnatal days 21) to adulthood (postnatal days 119) in three 
      different rearing conditions: (1) enriched, (2) standard and (3) isolated. We 
      found that long-term post-weaning environmental enrichment leads to lower 
      amygdala - and serum - BDNF levels as well as lower brain weights. Grouped 
      rearing in standard laboratory cages enhanced body weight. Thus, early rearing 
      condition might play a crucial role in adult healthiness by predetermining 
      individual BDNF profiles.
FAU - Babri, S
AU  - Babri S
AD  - 1Drug Applied Research Center,Tabriz University of Medical Sciences,Tabriz,Iran.
FAU - Mohaddes, G
AU  - Mohaddes G
AD  - 2Neuroscience Research Center,Tabriz University of Medical Sciences,Tabriz,Iran.
FAU - Mosaferi, B
AU  - Mosaferi B
AD  - 3Department of Basic Sciences,School of Nursing and Midwifery,Maragheh University 
      of Medical Sciences,Maragheh,Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180327
PL  - England
TA  - J Dev Orig Health Dis
JT  - Journal of developmental origins of health and disease
JID - 101517692
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
MH  - Amygdala/*metabolism
MH  - *Animal Husbandry
MH  - Animal Welfare
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Serum/*metabolism
OTO - NOTNLM
OT  - amygdala
OT  - brain-derived neurotrophic factor
OT  - early life experiences
OT  - environmental enrichment
OT  - psychiatric disorders
EDAT- 2018/03/28 06:00
MHDA- 2019/08/21 06:00
CRDT- 2018/03/28 06:00
PHST- 2018/03/28 06:00 [pubmed]
PHST- 2019/08/21 06:00 [medline]
PHST- 2018/03/28 06:00 [entrez]
AID - S2040174418000144 [pii]
AID - 10.1017/S2040174418000144 [doi]
PST - ppublish
SO  - J Dev Orig Health Dis. 2018 Aug;9(4):377-380. doi: 10.1017/S2040174418000144. 
      Epub 2018 Mar 27.