PMID- 29587799
OWN - NLM
STAT- MEDLINE
DCOM- 20190613
LR  - 20190613
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 16
IP  - 1
DP  - 2018 Mar 27
TI  - HLA alleles modulate EBV viral load in multiple sclerosis.
PG  - 80
LID - 10.1186/s12967-018-1450-6 [doi]
LID - 80
AB  - BACKGROUND: The etiopathology of multiple sclerosis (MS) is believed to include 
      genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in 
      particular,  are associated with disease susceptibility, whereas Epstein Barr 
      Virus (EBV) infection has long been suspected to play a role in disease 
      pathogenesis. The aim of the present study is to evaluate correlations between 
      HLA alleles and EBV infection in MS. METHODS: HLA alleles, EBV viral load (VL) 
      and serum anti-EBV antibody titers were evaluated in EBV-seropositive MS patients 
      (N = 117) and age- and sex-matched healthy controls (HC; N = 89). RESULTS: 
      Significantly higher DNA viral loads (p = 0.048) and EBNA-1 antibody titer 
      (p = 0.0004) were seen in MS compared to HC. EBV VL was higher in HLA-B*07+ 
      (p = 0.02) and HLA-DRB1*15+ (p = 0.02) MS patients, whereas it was lower in 
      HLA-A*02+ (p = 0.04) subjects. EBV VL was highest in HLA-A*02-/B*07+/DRB1*15+ 
      patients and lowest in HLA-A*A02+/B*07-/DRB1*15- individuals (p < 0.0001). 
      HLA-B*07 resulted the most associated allele to EBV VL after multiple regression 
      analysis considering altogether the three alleles, (p = 0.0001). No differences 
      were observed in anti-EBV antibody titers in relationship with HLA distribution. 
      CONCLUSIONS: Host HLA-B*07 allele influence EBV VL in MS. As HLA-class I 
      molecules present antigens to T lymphocytes and initiate immune response against 
      viruses, these results could support a role for EBV in MS.
FAU - Agostini, Simone
AU  - Agostini S
AUID- ORCID: 0000-0002-6214-0645
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy. 
      sagostini@dongnocchi.it.
FAU - Mancuso, Roberta
AU  - Mancuso R
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy.
FAU - Guerini, Franca R
AU  - Guerini FR
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy.
FAU - D'Alfonso, Sandra
AU  - D'Alfonso S
AD  - Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
FAU - Agliardi, Cristina
AU  - Agliardi C
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy.
FAU - Hernis, Ambra
AU  - Hernis A
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy.
FAU - Zanzottera, Milena
AU  - Zanzottera M
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy.
FAU - Barizzone, Nadia
AU  - Barizzone N
AD  - Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
FAU - Leone, Maurizio A
AU  - Leone MA
AD  - IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
FAU - Caputo, Domenico
AU  - Caputo D
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy.
FAU - Rovaris, Marco
AU  - Rovaris M
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy.
FAU - Clerici, Mario
AU  - Clerici M
AD  - Don C. Gnocchi Foundation IRCCS - ONLUS, Piazzale Morandi 3, 20121, Milan, Italy.
AD  - Department of Pathophysiology and Transplantation, University of Milan, Via 
      Fratelli Cervi 93, 20090, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180327
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Case-Control Studies
MH  - Cytomegalovirus/physiology
MH  - Female
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Herpesvirus 4, Human/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/blood/*genetics/*virology
MH  - Seroepidemiologic Studies
MH  - *Viral Load
PMC - PMC5870171
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - HLA-A*02
OT  - HLA-B*07
OT  - HLA-class I alleles
OT  - Immunogenetics
OT  - Multiple sclerosis
EDAT- 2018/03/29 06:00
MHDA- 2019/06/14 06:00
PMCR- 2018/03/27
CRDT- 2018/03/29 06:00
PHST- 2017/11/17 00:00 [received]
PHST- 2018/03/15 00:00 [accepted]
PHST- 2018/03/29 06:00 [entrez]
PHST- 2018/03/29 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/03/27 00:00 [pmc-release]
AID - 10.1186/s12967-018-1450-6 [pii]
AID - 1450 [pii]
AID - 10.1186/s12967-018-1450-6 [doi]
PST - epublish
SO  - J Transl Med. 2018 Mar 27;16(1):80. doi: 10.1186/s12967-018-1450-6.