PMID- 29588978
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220129
IS  - 2470-9239 (Print)
IS  - 2470-9239 (Electronic)
IS  - 2470-9239 (Linking)
VI  - 2
IP  - 4
DP  - 2017 Dec
TI  - Topography of generalized periodic epileptiform discharges in postanoxic 
      nonconvulsive status epilepticus.
PG  - 472-475
LID - 10.1002/epi4.12073 [doi]
AB  - We studied slow (</=2.5 Hz) nonevolving generalized periodic epileptiform 
      discharges (GPEDs) in the electroencephalogram (EEG) of comatose patients after 
      cardiac arrest (CA) in search of evidence that could assist early diagnosis of 
      possible hypoxic nonconvulsive status epilepticus (NCSE) and its differentiation 
      from terminal brain anoxia (BA), which can present with a similar EEG pattern. We 
      investigated the topography of the GPEDs in the first post-CA EEGs of 13 
      patients, using voltage-mapping, and compared findings between two patients with 
      NCSE and GPEDs > 2.5 Hz (group 1), and 11 with GPEDs </= 2 Hz, of whom six had 
      possible NCSE (group 2) and five had terminal BA (group 3). Voltage mapping 
      showed frontal maximum for the negative phase of the GPEDs in all patients of 
      groups 1 and 2, but not in any of the patients of group 3, who invariably showed 
      maximization of the negative phase posteriorly. Morphology, amplitude, and 
      duration of the GPEDs varied across the groups, without distinctive features for 
      possible NCSE. These findings provide evidence that, in hypoxic coma after CA 
      with slow GPEDs, anterior topography of the maximum GPED negativity on voltage 
      mapping may be a distinctive biomarker for possible NCSE contributing to the 
      coma.
FAU - Sakellariou, Dimitris Fotis
AU  - Sakellariou DF
AD  - Department of Clinical Neurophysiology and Epilepsy Guy's and St. Thomas' 
      National Health Service Foundation Trust London United Kingdom.
AD  - Division of Neuroscience Institute of Psychiatry, Psychology, and Neuroscience 
      King's College London London United Kingdom.
AD  - Neurophysiology Unit Department of Physiology School of Medicine University of 
      Patras Patras Greece.
FAU - Kostopoulos, George Kostantinos
AU  - Kostopoulos GK
AD  - Neurophysiology Unit Department of Physiology School of Medicine University of 
      Patras Patras Greece.
FAU - Richardson, Mark Philip
AU  - Richardson MP
AD  - Division of Neuroscience Institute of Psychiatry, Psychology, and Neuroscience 
      King's College London London United Kingdom.
FAU - Koutroumanidis, Michalis
AU  - Koutroumanidis M
AD  - Department of Clinical Neurophysiology and Epilepsy Guy's and St. Thomas' 
      National Health Service Foundation Trust London United Kingdom.
AD  - Division of Neuroscience Institute of Psychiatry, Psychology, and Neuroscience 
      King's College London London United Kingdom.
LA  - eng
GR  - MR/K013998/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20170821
PL  - United States
TA  - Epilepsia Open
JT  - Epilepsia open
JID - 101692036
PMC - PMC5862105
OTO - NOTNLM
OT  - Cardiac arrest
OT  - EEG
OT  - Hypoxic coma
OT  - Intensive care
OT  - Voltage maps
EDAT- 2018/03/29 06:00
MHDA- 2018/03/29 06:01
PMCR- 2017/08/21
CRDT- 2018/03/29 06:00
PHST- 2017/07/13 00:00 [accepted]
PHST- 2018/03/29 06:00 [entrez]
PHST- 2018/03/29 06:00 [pubmed]
PHST- 2018/03/29 06:01 [medline]
PHST- 2017/08/21 00:00 [pmc-release]
AID - EPI412073 [pii]
AID - 10.1002/epi4.12073 [doi]
PST - epublish
SO  - Epilepsia Open. 2017 Aug 21;2(4):472-475. doi: 10.1002/epi4.12073. eCollection 
      2017 Dec.