PMID- 29589508
OWN - NLM
STAT- MEDLINE
DCOM- 20190701
LR  - 20190701
IS  - 1543-5474 (Electronic)
IS  - 1543-3080 (Linking)
VI  - 15
IP  - 8
DP  - 2018 Aug 1
TI  - A Longitudinal Analysis of the Relationships of Physical Activity and Body Fat 
      With Nerve Growth Factor and Brain-Derived Neural Factor in Children.
PG  - 620-625
LID - 10.1123/jpah.2017-0483 [doi]
AB  - BACKGROUND: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are 
      important for brain function and detectable in the blood. This study explored the 
      longitudinal associations of physical activity and body fat with serum NGF and 
      BDNF in children. METHODS: Two waves of measurements were performed 2 years apart 
      in 8- to 11-year-old children, including physical activity using the ActiGraph 
      model 7164, body composition by dual-energy X-ray absorptiometry, and serum NGF 
      and BDNF determined by multiplex immunoassay. The first wave included 248 
      children. Full information maximum likelihood estimation with robust standard 
      errors was applied in structural equation modeling. RESULTS: Vigorous physical 
      activity showed a direct positive longitudinal relationship with NGF 
      (standardized coefficient beta = 0.30, P = .01) but not with BDNF (beta = 0.04, 
      P = .84). At the same time, body fat percentage was positively related to both 
      NGF (beta = 0.59, P < .001) and BDNF (beta = 0.17, P = .04). There was an indication of 
      an indirect relationship of vigorous physical activity with NGF (product of 
      unstandardized coefficient beta = -0.18, P = .02) and BDNF (beta = -0.07, P = .05) 
      through the negative relationship with body fat percentage (beta = -0.36, P < .001). 
      CONCLUSIONS: Vigorous physical activity is directly related to serum NGF and 
      indirectly through the level of body fat. The relationships with serum BDNF are 
      more complex.
FAU - Arvidsson, Daniel
AU  - Arvidsson D
FAU - Johannesson, Elias
AU  - Johannesson E
FAU - Andersen, Lars Bo
AU  - Andersen LB
FAU - Karlsson, Magnus
AU  - Karlsson M
FAU - Wollmer, Per
AU  - Wollmer P
FAU - Thorsson, Ola
AU  - Thorsson O
FAU - Dencker, Magnus
AU  - Dencker M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180328
PL  - United States
TA  - J Phys Act Health
JT  - Journal of physical activity & health
JID - 101189457
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NGF protein, human)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Accelerometry
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Brain/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Nerve Growth Factor/*blood
OTO - NOTNLM
OT  - accelerometer
OT  - dual-energy X-ray absorptiometry
OT  - neurotrophins
OT  - serum
OT  - structural equation modeling
EDAT- 2018/03/29 06:00
MHDA- 2019/07/02 06:00
CRDT- 2018/03/29 06:00
PHST- 2018/03/29 06:00 [pubmed]
PHST- 2019/07/02 06:00 [medline]
PHST- 2018/03/29 06:00 [entrez]
AID - 10.1123/jpah.2017-0483 [doi]
PST - ppublish
SO  - J Phys Act Health. 2018 Aug 1;15(8):620-625. doi: 10.1123/jpah.2017-0483. Epub 
      2018 Mar 28.