PMID- 29593065
OWN - NLM
STAT- MEDLINE
DCOM- 20190627
LR  - 20190627
IS  - 1549-5477 (Electronic)
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 32
IP  - 5-6
DP  - 2018 Mar 1
TI  - A bone marrow niche-derived molecular switch between osteogenesis and 
      hematopoiesis.
PG  - 324-326
LID - 10.1101/gad.314013.118 [doi]
AB  - Hematopoietic stem cells (HSCs) reside and are maintained in specialized 
      microenvironments within the bone marrow known as niches, which are comprised of 
      various cell types. Among them, leptin receptor (LepR)-expressing CXC chemokine 
      ligand 12 (CXCL12)-abundant reticular (CAR) cells are known to create a niche for 
      HSCs and at the same time to give rise to osteoblasts. These two functions of 
      CAR/LepR(+) cells appear to be tightly but inversely regulated to ensure adequate 
      physical space for HSCs. However, how osteogenesis is prevented in CAR cells to 
      maintain spaces available for HSCs and hematopoiesis remains unclear. In this 
      issue of Genes & Development, Seike and colleagues (pp. 359-372) report that the 
      transcription factor early B-cell factor (Ebf3) is preferentially expressed by 
      CAR/LepR(+) cells and inhibits CAR cell differentiation into osteoblasts while at 
      the same time maintaining self-renewal of CAR/LepR(+) cells. Using conditional 
      knockout and retroviral systems, the investigators show that loss of Ebf3 in CAR 
      cells impairs HSC numbers and leads to osteosclerosis. This study provides novel 
      insights into transcriptional requirements for CAR cell bone formation by 
      identifying Ebf3 as a niche factor secreted from CAR/Lepr(+) cells that regulates 
      the interplay between osteogenesis and hematopoiesis.
CI  - (c) 2018 Galan-Diez and Kousteni; Published by Cold Spring Harbor Laboratory Press.
FAU - Galan-Diez, Marta
AU  - Galan-Diez M
AD  - Department of Physiology and Cellular Biophysics, College of Physicians and 
      Surgeons, Columbia University, New York, New York 10032, USA.
FAU - Kousteni, Stavroula
AU  - Kousteni S
AD  - Department of Physiology and Cellular Biophysics, College of Physicians and 
      Surgeons, Columbia University, New York, New York 10032, USA.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
SB  - IM
CON - Genes Dev. 2018 Mar 1;32(5-6):359-372. PMID: 29563184
MH  - Bone Marrow
MH  - Hematopoiesis
MH  - Hematopoietic Stem Cells
MH  - *Osteogenesis
MH  - *Stem Cell Niche
PMC - PMC5900706
OTO - NOTNLM
OT  - Ebf3
OT  - bone
OT  - hematopoietic stem cell
OT  - mesenchymal stem cell
OT  - stem cell niche
EDAT- 2018/03/30 06:00
MHDA- 2019/06/30 06:00
PMCR- 2018/09/01
CRDT- 2018/03/30 06:00
PHST- 2018/03/30 06:00 [entrez]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - 32/5-6/324 [pii]
AID - 10.1101/gad.314013.118 [doi]
PST - ppublish
SO  - Genes Dev. 2018 Mar 1;32(5-6):324-326. doi: 10.1101/gad.314013.118.