PMID- 29594243
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2405-6308 (Electronic)
IS  - 2405-6308 (Linking)
VI  - 9
DP  - 2018 Feb
TI  - Resolution of atelectasis during radiochemotherapy of lung cancer with serious 
      implications for further treatment. A case report.
PG  - 1-4
LID - 10.1016/j.ctro.2017.12.001 [doi]
AB  - Local failure is a major cause for low overall survival rates in advanced non 
      small cell lung cancer (NSCLC). Among others, radioresistant tumor clones as well 
      as geographical miss can explain these high local failure rates. One reason for 
      geographical miss is a change of tumor related atelectasis in the course of 
      radiotherapy. We present the case of a patient with UICC Stage IIIb NSCLC who 
      presented with a large tumor related atelectasis. During definitive 
      radiochemotherapy, the atelectasis resolved, which resulted in a massive tumor 
      shift out of the planning target volume within 2 days. Without close monitoring 
      by cone beam CTs and prompt replanning, this would have led to a geographical 
      miss and relevant underdosage of the tumor. Furthermore, changes in anatomy and 
      pulmonary function during treatment had implications for organs at risk and 
      opened windows for dose escalation. We suggest at least biweekly CBCTs in 
      patients with poststenotic atelectasis to ensure the rapid detection of 
      geographical changes of the target and subsequent intervention if necessary.
FAU - Braun, Lore Helene
AU  - Braun LH
AD  - Department of Radiation Oncology, University Hospital Tubingen, Hoppe-Seyler-Str. 
      3, 72076 Tubingen, Germany.
FAU - Welz, Stefan
AU  - Welz S
AD  - Department of Radiation Oncology, University Hospital Tubingen, Hoppe-Seyler-Str. 
      3, 72076 Tubingen, Germany.
FAU - Viehrig, Maren
AU  - Viehrig M
AD  - Department of Radiation Oncology, University Hospital Tubingen, Hoppe-Seyler-Str. 
      3, 72076 Tubingen, Germany.
FAU - Heinzelmann, Frank
AU  - Heinzelmann F
AD  - Department of Radiation Oncology, University Hospital Tubingen, Hoppe-Seyler-Str. 
      3, 72076 Tubingen, Germany.
FAU - Zips, Daniel
AU  - Zips D
AD  - Department of Radiation Oncology, University Hospital Tubingen, Hoppe-Seyler-Str. 
      3, 72076 Tubingen, Germany.
FAU - Gani, Cihan
AU  - Gani C
AD  - Department of Radiation Oncology, University Hospital Tubingen, Hoppe-Seyler-Str. 
      3, 72076 Tubingen, Germany.
LA  - eng
PT  - Case Reports
DEP - 20171208
PL  - Ireland
TA  - Clin Transl Radiat Oncol
JT  - Clinical and translational radiation oncology
JID - 101713416
PMC - PMC5862676
EDAT- 2018/03/30 06:00
MHDA- 2018/03/30 06:01
PMCR- 2017/12/08
CRDT- 2018/03/30 06:00
PHST- 2017/11/16 00:00 [received]
PHST- 2017/12/05 00:00 [revised]
PHST- 2017/12/06 00:00 [accepted]
PHST- 2018/03/30 06:00 [entrez]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2018/03/30 06:01 [medline]
PHST- 2017/12/08 00:00 [pmc-release]
AID - S2405-6308(17)30094-0 [pii]
AID - 10.1016/j.ctro.2017.12.001 [doi]
PST - epublish
SO  - Clin Transl Radiat Oncol. 2017 Dec 8;9:1-4. doi: 10.1016/j.ctro.2017.12.001. 
      eCollection 2018 Feb.