PMID- 29595373
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20190215
IS  - 2242-3982 (Electronic)
IS  - 1239-9736 (Print)
IS  - 1239-9736 (Linking)
VI  - 77
IP  - 1
DP  - 2018 Dec
TI  - Persistent organic pollutants and haematological markers in Greenlandic pregnant 
      women: the ACCEPT sub-study.
PG  - 1456303
LID - 10.1080/22423982.2018.1456303 [doi]
LID - 1456303
AB  - The Arctic populations have high blood concentrations of persistent organic 
      pollutants (POPs). Exposure to POPs was related to adverse health effects e.g. 
      immune, neurological and reproductive systems. This study investigates 
      associations between serum POP levels and haematological markers in Greenlandic 
      pregnant women. This cross-sectional study included 189 women enrolled in 
      2010-2011 at the Greenlandic West coast by the inclusion criteria >/=18 years of 
      age and had lived for 50% or more of their life in Greenland. The associations 
      between the sum of the POP variables polychlorinated biphenyls (sumPCBs), 
      organochlorine pesticides (sumOCPs), perfluoroalkylated substances (sumPFASs) and 
      24 haematological markers were analysed using linear regression adjusted for age, 
      pre-pregnancy BMI, parity, gestation week, plasma-cotinine and alcohol intake. It 
      showed a significantly inverse association between several haematological markers 
      (eosinophil, lymphocyte, neutrophil and white blood cells) and sumPCBs, sumOCPs 
      and sumPFASs. In addition, the monocyte, mean corpuscular haemoglobin 
      concentration, plateletcrit and platelet count markers were significantly 
      inversely associated with sumPFASs, but the haematocrit and mean erythrocyte 
      corpuscular volume were positively associated with sumPFASs. In conclusion, 
      exposure to POPs influenced several haematological markers, especially cell count 
      parameters, suggesting immunosuppressive potential of POPs in Greenlandic 
      pregnant women. The data need further investigations.
FAU - Knudsen, Ane-Kersti Skaarup
AU  - Knudsen AS
AD  - a Centre for Arctic Health & Molecular Epidemiology, Department of Public Health 
      , Aarhus University , Aarhus , Denmark.
AD  - b Emergency Department , Regional Hospital of Randers , Randers , Denmark.
FAU - Long, Manhai
AU  - Long M
AD  - a Centre for Arctic Health & Molecular Epidemiology, Department of Public Health 
      , Aarhus University , Aarhus , Denmark.
FAU - Pedersen, Henning Sloth
AU  - Pedersen HS
AD  - c Primary Health Care Center , Queen Ingrid Hospital , Nuuk , Greenland.
FAU - Bonefeld-Jorgensen, Eva Cecilie
AU  - Bonefeld-Jorgensen EC
AD  - a Centre for Arctic Health & Molecular Epidemiology, Department of Public Health 
      , Aarhus University , Aarhus , Denmark.
AD  - d Greenland Center for Health Research , University of Greenland , Nuuk , 
      Greenland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Circumpolar Health
JT  - International journal of circumpolar health
JID - 9713056
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Cotinine/blood
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*adverse effects
MH  - Female
MH  - Fluorocarbons/blood
MH  - Gestational Age
MH  - Greenland/epidemiology
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Parity
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Pregnancy/*blood
MH  - Young Adult
PMC - PMC5912198
OTO - NOTNLM
OT  - Inuit
OT  - Persistent organic pollutants
OT  - blood samples
OT  - haematological markers
OT  - pregnancy
EDAT- 2018/03/30 06:00
MHDA- 2019/02/08 06:00
PMCR- 2018/01/01
CRDT- 2018/03/30 06:00
PHST- 2018/03/30 06:00 [entrez]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 1456303 [pii]
AID - 10.1080/22423982.2018.1456303 [doi]
PST - ppublish
SO  - Int J Circumpolar Health. 2018 Dec;77(1):1456303. doi: 
      10.1080/22423982.2018.1456303.