PMID- 29595641
OWN - NLM
STAT- MEDLINE
DCOM- 20180405
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 13
DP  - 2018 Mar
TI  - Childhood trauma interacted with BDNF Val66Met influence schizophrenic symptoms.
PG  - e0160
LID - 10.1097/MD.0000000000010160 [doi]
LID - e0160
AB  - The gene - environment (G x E) interaction effect is involved in severe mental 
      disorders. However, whether the brain-derived neurotrophic factor (BDNF) Val66Met 
      polymorphism participates in the childhood-abuse influenced schizophrenic 
      symptoms remains unclear. We examined the interaction between BDNF Val66Met, and 
      childhood trauma (ChT) on psychotic symptoms in a Chinese Han population.To 
      estimate the G x E interaction, psychiatric interviews, self-report 
      questionnaires for ChT, and genotyping for BDNF Val66Met were carried out on 201 
      schizophrenic patients. G x E interactions were analyzed by generalized 
      multifactor dimensionality reduction (GMDR).Among all patients, 11.9%, 19.4%, 
      23.4%, 26.4%, and 73.6% reported emotional abuses, physical abuses (PA), sexual 
      abuses (SA), emotional neglects (EN), and physical neglects (PN), respectively. 
      Significant negative correlations were observed between anxiety/depression 
      factors, and ChT total scores. Patients with 3 different BDNF genotypes showed 
      significant differences in anxiety/depression scores. Significant 2-way 
      interactions were found for Val66Met x PN, 3-way interactions were found for 
      Val66Met x PN x PA, and four-way interactions were found for 
      Val66Met x PN x PA x EN with regard to the excitement scores.Our findings 
      suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk 
      for schizophrenia symptoms.
FAU - Bi, Xiao-Jiao
AU  - Bi XJ
AD  - Department of Psychiatry, Shandong Mental Health Center, Jinan, Shandong 
      Province, P.R. China.
FAU - Lv, Xiao-Min
AU  - Lv XM
FAU - Ai, Xian-Ying
AU  - Ai XY
FAU - Sun, Meng-Meng
AU  - Sun MM
FAU - Cui, Kai-Yan
AU  - Cui KY
FAU - Yang, Li-Min
AU  - Yang LM
FAU - Wang, Li-Na
AU  - Wang LN
FAU - Yin, Ai-Hua
AU  - Yin AH
FAU - Liu, Lan-Fen
AU  - Liu LF
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child Abuse/*psychology
MH  - China
MH  - Female
MH  - Gene-Environment Interaction
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Schizophrenia/*genetics
MH  - Young Adult
PMC - PMC5895403
COIS- Conflict of Interest: The authors declare that they have no competing interests.
EDAT- 2018/03/30 06:00
MHDA- 2018/04/06 06:00
PMCR- 2018/03/30
CRDT- 2018/03/30 06:00
PHST- 2018/03/30 06:00 [entrez]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2018/04/06 06:00 [medline]
PHST- 2018/03/30 00:00 [pmc-release]
AID - 00005792-201803300-00014 [pii]
AID - MD-D-17-07615 [pii]
AID - 10.1097/MD.0000000000010160 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Mar;97(13):e0160. doi: 10.1097/MD.0000000000010160.