PMID- 29596923
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20200225
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 347
DP  - 2018 May 15
TI  - Effects of continuous bisphenol A exposure from early gestation on 90 day old rat 
      testes function and sperm molecular profiles: A CLARITY-BPA consortium study.
PG  - 1-9
LID - S0041-008X(18)30107-8 [pii]
LID - 10.1016/j.taap.2018.03.021 [doi]
AB  - Bisphenol A (BPA) is a ubiquitous industrial chemical that has been identified as 
      an endocrine disrupting compound (EDC). There is growing concern that early life 
      exposures to EDCs, such as BPA, can adversely affect the male reproductive tract 
      and function. This study was conducted as part of the Consortium Linking Academic 
      and Regulatory Insights on BPA Toxicity (CLARITY-BPA) to further delineate the 
      toxicities associated with continuous exposure to BPA from early gestation, and 
      to comprehensively examine the elicited effects on testes and sperm. NCTR Sprague 
      Dawley rat dams were gavaged from gestational day (GD) 6 until parturition, and 
      their pups were directly gavaged daily from postnatal day (PND) 1 to 90 with BPA 
      (2.5, 25, 250, 2500, 25,000, 250,000 mug/kg/d) or vehicle control. At PND 90, the 
      testes and sperm were collected for evaluation. The testes were histologically 
      evaluated for altered germ cell apoptosis, sperm production, and altered 
      spermiation. RNA and DNA isolated from sperm were assessed for elicited changes 
      in global mRNA transcript abundance and altered DNA methylation. Effects of BPA 
      were observed in changes in body, testis and epididymis weights only at the 
      highest administered dose of BPA of 250,000 mug/kg/d. Genome-wide transcriptomic 
      and epigenomic analyses failed to detect robust alterations in sperm mRNA and DNA 
      methylation levels. These data indicate that prolonged exposure starting in utero 
      to BPA over a wide range of levels has little, if any, impact on the testes and 
      sperm molecular profiles of 90 day old rats as assessed by the histopathologic, 
      morphometric, and molecular endpoints evaluated.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Dere, Edward
AU  - Dere E
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      RI, United States; Division of Urology, Rhode Island Hospital, Providence, RI, 
      United States.
FAU - Anderson, Linnea M
AU  - Anderson LM
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      RI, United States.
FAU - Huse, Susan M
AU  - Huse SM
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      RI, United States.
FAU - Spade, Daniel J
AU  - Spade DJ
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      RI, United States.
FAU - McDonnell-Clark, Elizabeth
AU  - McDonnell-Clark E
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      RI, United States.
FAU - Madnick, Samantha J
AU  - Madnick SJ
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      RI, United States.
FAU - Hall, Susan J
AU  - Hall SJ
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      RI, United States.
FAU - Camacho, Luisa
AU  - Camacho L
AD  - Division of Biochemical Toxicology, National Center for Toxicological Research, 
      Jefferson, AR, United States.
FAU - Lewis, Sherry M
AU  - Lewis SM
AD  - Office of Scientific Coordination, National Center for Toxicological Research, 
      Jefferson, AR, United States.
FAU - Vanlandingham, Michelle M
AU  - Vanlandingham MM
AD  - Division of Biochemical Toxicology, National Center for Toxicological Research, 
      Jefferson, AR, United States.
FAU - Boekelheide, Kim
AU  - Boekelheide K
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      RI, United States. Electronic address: kim_boekelheide@brown.edu.
LA  - eng
GR  - T32 ES007272/ES/NIEHS NIH HHS/United States
GR  - U01 ES020913/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180326
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Benzhydryl Compounds/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Gestational Age
MH  - Male
MH  - Maternal Exposure/adverse effects
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats, Sprague-Dawley
MH  - Sperm Count
MH  - Spermatogenesis/drug effects
MH  - Spermatozoa/*drug effects/metabolism/pathology
MH  - Testis/*drug effects/embryology/metabolism/pathology
PMC - PMC6412024
MID - NIHMS1016139
EDAT- 2018/03/30 06:00
MHDA- 2018/10/30 06:00
PMCR- 2019/05/15
CRDT- 2018/03/30 06:00
PHST- 2017/11/29 00:00 [received]
PHST- 2018/02/28 00:00 [revised]
PHST- 2018/03/19 00:00 [accepted]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
PHST- 2018/03/30 06:00 [entrez]
PHST- 2019/05/15 00:00 [pmc-release]
AID - S0041-008X(18)30107-8 [pii]
AID - 10.1016/j.taap.2018.03.021 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2018 May 15;347:1-9. doi: 10.1016/j.taap.2018.03.021. 
      Epub 2018 Mar 26.