PMID- 29596995
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20190415
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 86
DP  - 2018 Aug 30
TI  - Applying ketamine to alleviate the PTSD-like effects by regulating the 
      HCN1-related BDNF.
PG  - 313-321
LID - S0278-5846(18)30019-8 [pii]
LID - 10.1016/j.pnpbp.2018.03.019 [doi]
AB  - BACKGROUND: Post-traumatic stress disorder (PTSD) is commonly associated with 
      concurrent anxiety and depression symptoms, and reduce the expression of the 
      Brain-Derived Neurotrophic Factor (BDNF) which promotes the proliferation and 
      survival of neurons. The hyperpolarization-activated cyclic nucleotide-gated 
      channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate 
      depression and anxiety, and regulated the BDNF expression, however, the effects 
      of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have 
      been poorly perceived. METHODS: In the present study, the effects of ketamine 
      were examined on the PTSD-like effects in a rat model of PTSD induced by SPS&S 
      procedure. After the SPS&S procedure and model testing, PTSD rats were subjected 
      to behavioral testing and biochemical assessments, followed by single treatment 
      with certain doses of ketamine (5, 10, 15 and 20 mg/kg IP). RESULTS: The results 
      showed that the SPS&S procedure induced severe PTSD-like behaviors, with lower 
      levels of BDNF protein levels and higher level of the HCN1 protein in the 
      prefrontal cortex (PFC). These were reversed by a single administration of 
      ketamine. The ketamine with dose of 15 mg/kg significantly increased locomotor 
      behavior in the open field test, aggrandized exploratory behavior in the elevated 
      plus maze test, and decreased immobility time spent in the forced swim test. 
      Meanwhile, ketamine with dose of 15 mg/kg could increase the BDNF protein level, 
      while down-regulate the expression of the HCN1. Eventually, there was a negative 
      correlation between the level of BDNF and HCN1 in the PFC. CONCLUSION: Ketamine 
      affects the HCN1-related BDNF signaling pathways to alleviate PTSD-like effects 
      in rat.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Hou, Lanwei
AU  - Hou L
AD  - Department of Clinical Medicine, Weifang Medical University, 7166# Baotong West 
      Street, Weifang, 261053, Shandong, China.
FAU - Qi, Yirui
AU  - Qi Y
AD  - Department of Clinical Medicine, Weifang Medical University, 7166# Baotong West 
      Street, Weifang, 261053, Shandong, China.
FAU - Sun, Hongwei
AU  - Sun H
AD  - Department of Psychology, Weifang Medical University, 7166# Baotong West Street, 
      Weifang, 261053, Shandong, China.
FAU - Wang, Gang
AU  - Wang G
AD  - Laboratory for Cognitive Neuroscience, Weifang Medical University, 7166# Baotong 
      West Street, Weifang, 261053, Shandong, China.
FAU - Li, Qi
AU  - Li Q
AD  - Department of Psychiatry, Centre for Reproduction Growth and Development, 
      University of Hong Kong, China.
FAU - Wang, Yanyu
AU  - Wang Y
AD  - Department of Psychology, Weifang Medical University, 7166# Baotong West Street, 
      Weifang, 261053, Shandong, China.
FAU - Zhang, Zuoji
AU  - Zhang Z
AD  - Behavior Medical Education Research Center, Jining Medical University, NO. 16 
      Hehua Road, Taibaihu District, Jining, 272067, Shandong, China.
FAU - Du, Zhongde
AU  - Du Z
AD  - Department of Neurology, Chinese People's Liberation Army Eighty-Nine Hospital, 
      256# Beigong West Street, Weifang, 261021, Shandong, China.
FAU - Sun, Lin
AU  - Sun L
AD  - Department of Clinical Medicine, Weifang Medical University, 7166# Baotong West 
      Street, Weifang, 261053, Shandong, China; Department of Psychology, Weifang 
      Medical University, 7166# Baotong West Street, Weifang, 261053, Shandong, China. 
      Electronic address: linsun2013@wfmc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180327
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hcn1 protein, rat)
RN  - 0 (Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels)
RN  - 0 (Potassium Channels)
RN  - 0 (Psychotropic Drugs)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*metabolism
MH  - Ketamine/*pharmacology
MH  - Male
MH  - Potassium Channels/*metabolism
MH  - Prefrontal Cortex/drug effects/metabolism/pathology
MH  - Psychotropic Drugs/*pharmacology
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects
MH  - Stress Disorders, Post-Traumatic/*drug therapy/*metabolism/pathology
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Hyperpolarization-activated cyclic nucleotide-gated channel 1
OT  - Ketamine
OT  - Post-traumatic stress disorder
OT  - Prefrontal cortex
EDAT- 2018/03/30 06:00
MHDA- 2019/04/16 06:00
CRDT- 2018/03/30 06:00
PHST- 2018/01/10 00:00 [received]
PHST- 2018/03/07 00:00 [revised]
PHST- 2018/03/23 00:00 [accepted]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PHST- 2018/03/30 06:00 [entrez]
AID - S0278-5846(18)30019-8 [pii]
AID - 10.1016/j.pnpbp.2018.03.019 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 30;86:313-321. doi: 
      10.1016/j.pnpbp.2018.03.019. Epub 2018 Mar 27.