PMID- 29597000
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1878-1519 (Electronic)
IS  - 1569-9048 (Linking)
VI  - 257
DP  - 2018 Nov
TI  - Cough reflex sensitivity does not correlate with the esophageal sensitivity to 
      acid in patients with gastroesophageal reflux disease.
PG  - 25-29
LID - S1569-9048(17)30392-0 [pii]
LID - 10.1016/j.resp.2018.03.011 [doi]
AB  - The sensitization of cough reflex observed in patients with gastroesophageal 
      reflux disease (GERD) is attributed to activation of vagal C-fibers innervating 
      the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid 
      sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the 
      relationship between cough reflex sensitivity (CRS) and esophageal sensitivity to 
      acid. We evaluated CRS to capsaicin inhalation and esophageal sensitivity to acid 
      (intensity of heartburn evoked by esophageal infusions of acid pH = 3, 2 and 1) 
      in patients with GERD and chronic heartburn before and 3 months after proton pump 
      inhibitor (PPI) treatment. There was no correlation between CRS and esophageal 
      sensitivity to acid at any pH tested. PPI treatment substantially reduced 
      esophageal sensitivity to acid but did not affect CRS. We conclude that a simple 
      direct relationship between CRS and esophageal sensitivity to acid is unlikely. 
      The results indicate that spinal and vagal afferent pathways from the esophagus 
      are probably influenced separately in subjects with GERD.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Duricek, Martin
AU  - Duricek M
AD  - Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM 
      CU), Gastroenterology Clinic JFM CU, Slovakia.
FAU - Nosakova, Lenka
AU  - Nosakova L
AD  - Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM 
      CU), Gastroenterology Clinic JFM CU, Slovakia.
FAU - Zatko, Tomas
AU  - Zatko T
AD  - Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM 
      CU), Department of Pathophysiology JFM CU, Slovakia.
FAU - Pecova, Renata
AU  - Pecova R
AD  - Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM 
      CU), Department of Pathophysiology JFM CU, Slovakia.
FAU - Hyrdel, Rudolf
AU  - Hyrdel R
AD  - Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM 
      CU), Gastroenterology Clinic JFM CU, Slovakia.
FAU - Banovcin, Peter Jr
AU  - Banovcin P Jr
AD  - Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM 
      CU), Gastroenterology Clinic JFM CU, Slovakia. Electronic address: 
      pbanovcin@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180327
PL  - Netherlands
TA  - Respir Physiol Neurobiol
JT  - Respiratory physiology & neurobiology
JID - 101140022
SB  - IM
MH  - Cough/*physiopathology/therapy
MH  - Esophagus/*physiopathology
MH  - Female
MH  - Gastroesophageal Reflux/*physiopathology/therapy
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Reflex/physiology
OTO - NOTNLM
OT  - Cough
OT  - Cough reflex sensitivity
OT  - Esophageal sensitivity
OT  - Gastroesophageal reflux
OT  - Vagus nerve
EDAT- 2018/03/30 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/03/30 06:00
PHST- 2017/11/13 00:00 [received]
PHST- 2018/03/17 00:00 [revised]
PHST- 2018/03/21 00:00 [accepted]
PHST- 2018/03/30 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/03/30 06:00 [entrez]
AID - S1569-9048(17)30392-0 [pii]
AID - 10.1016/j.resp.2018.03.011 [doi]
PST - ppublish
SO  - Respir Physiol Neurobiol. 2018 Nov;257:25-29. doi: 10.1016/j.resp.2018.03.011. 
      Epub 2018 Mar 27.