PMID- 29597287
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20221207
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 4
DP  - 2018 Mar 28
TI  - Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and 
      Obesity: A Family-Based Study in China.
LID - 10.3390/ijms19041011 [doi]
LID - 1011
AB  - C-Maf Inducing Protein (CMIP) gene polymorphisms were reported to be associated 
      with type 2 diabetes mellitus (T2DM). Whether the association between CMIP and 
      T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the 
      association of CMIP rs2925979 with T2DM and a comprehensive set of 
      obesity-related phenotypes in 1576 families ascertained from a Chinese 
      population. These families included a total of 3444 siblings (1582 with T2DM, 963 
      with prediabetes, and 899 with a normal glucose level). Using multi-level mixed 
      effects regression models, we found that each copy of CMIP rs2925979_T allele was 
      associated with a 29% higher risk of T2DM in females (p = 9.30 x 10(-4)), while 
      it was not significantly associated with T2DM in males (p = 0.705). Meanwhile, 
      rs2925979_T allele was associated with lower levels of body mass index (BMI), 
      waist circumference (WC), hip circumference (HC), percentage of body fat (PBF), 
      PBF of arms, PBF of legs, and PBF of trunk in nondiabetes females (all p < 0.05). 
      The opposite associations of rs2925979_T allele with T2DM and obesity-related 
      phenotypes suggest that CMIP may exert independent pleiotropic effects on T2DM 
      and obesity-related phenotypes in females.
FAU - Cao, Yaying
AU  - Cao Y
AUID- ORCID: 0000-0002-5024-2652
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China. cyyenjoy@126.com.
FAU - Wang, Tao
AU  - Wang T
AD  - Department of Epidemiology and Population Health, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA. tao.wang@einstein.yu.edu.
FAU - Wu, Yiqun
AU  - Wu Y
AUID- ORCID: 0000-0002-5554-1678
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China. qywu118@163.com.
FAU - Juan, Juan
AU  - Juan J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China. juanjuan@bjmu.edu.cn.
FAU - Qin, Xueying
AU  - Qin X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China. xueyingqin@gmail.com.
FAU - Tang, Xun
AU  - Tang X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China. tangxun@bjmu.edu.cn.
FAU - Wu, Tao
AU  - Wu T
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China. twu@bjmu.edu.cn.
FAU - Hu, Yonghua
AU  - Hu Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing 100191, China. yhhu@bjmu.edu.cn.
LA  - eng
GR  - P30 DK020541/DK/NIDDK NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180328
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CMIP protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Asian People
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/epidemiology/*genetics
MH  - *Polymorphism, Genetic
MH  - Sex Factors
PMC - PMC5979311
OTO - NOTNLM
OT  - CMIP
OT  - family-based study
OT  - obesity
OT  - pleiotropic genetic effects
OT  - sex-specific pattern
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2018/03/31 06:00
MHDA- 2018/09/06 06:00
PMCR- 2018/04/01
CRDT- 2018/03/31 06:00
PHST- 2018/02/09 00:00 [received]
PHST- 2018/03/23 00:00 [revised]
PHST- 2018/03/26 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - ijms19041011 [pii]
AID - ijms-19-01011 [pii]
AID - 10.3390/ijms19041011 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Mar 28;19(4):1011. doi: 10.3390/ijms19041011.