PMID- 29599679
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 1642-395X (Print)
IS  - 2299-0046 (Electronic)
IS  - 1642-395X (Linking)
VI  - 35
IP  - 1
DP  - 2018 Feb
TI  - Seasonal variation of asthma control, lung function tests and allergic 
      inflammation in relation to vitamin D levels: a prospective annual study.
PG  - 99-105
LID - 10.5114/ada.2017.71421 [doi]
AB  - INTRODUCTION: There are scarce data about the role of vitamin D (vitD) in asthma 
      control related to seasons and other confounders. AIM: To investigate the 
      seasonal relationship between vitD levels and asthma control, lung function tests 
      (LFTs) and cytokines during a 1-year period, among 7-17-year-old asthmatic 
      children. MATERIAL AND METHODS: Thirty patients with asthma with house dust mite 
      monosensitization were evaluated 3 monthly about the previous month's health and 
      vitD related lifestyle factors and asthma control test (ACT), spirometry and 
      bronchial provocation test for a year. Serum vitD, vitD binding protein (VDBP), 
      total IgE levels, absolute eosinophil and Treg counts and cytokine levels were 
      simultaneously measured. The seasonal changes of vitD and other parameters and 
      the relationship between 120 pooled data sets of vitD and major outcomes were 
      evaluated. RESULTS: Mean vitD levels, forced expiratory volume in 1 s (FEV(1)%) 
      and ACT score were lowest in winter and highest in summer. Pooled vitD levels 
      were positively correlated with pooled ACT scores, Treg counts, FEV(1)% values 
      and VDBP levels and negatively with total immunoglobulin E (IgE) and 
      interleukin-4 (IL-4) levels and bronchodilator response. VitD levels were 
      positively associated with ACT score, and FEV(1)% value and negatively with serum 
      IgE level and bronchodilator response after adjusting for confounders. 
      CONCLUSIONS: This study revealed that asthma control measures, LFTs and IgE 
      levels were significantly related to serum vitD levels, independent from age, 
      body mass index, inhaled corticosteroid use, sun exposure and season among 
      asthmatic children. Vitamin D levels showed a positive correlation with Treg 
      counts and a negative correlation with Th2 type cytokines.
FAU - Batmaz, Sehra Birgul
AU  - Batmaz SB
AD  - Department of Pediatric Allergy and Immunology, Tokat State Hospital, Tokat, 
      Turkey.
FAU - Arikoglu, Tugba
AU  - Arikoglu T
AD  - Department of Pediatric Allergy and Immunology, Faculty of Medicine, Mersin 
      University, Mersin, Turkey.
FAU - Tamer, Lulufer
AU  - Tamer L
AD  - Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, 
      Turkey.
FAU - Eskandari, Gulcin
AU  - Eskandari G
AD  - Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, 
      Turkey.
FAU - Kuyucu, Semanur
AU  - Kuyucu S
AD  - Department of Pediatric Allergy and Immunology, Faculty of Medicine, Mersin 
      University, Mersin, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180220
PL  - Poland
TA  - Postepy Dermatol Alergol
JT  - Postepy dermatologii i alergologii
JID - 101168357
PMC - PMC5872241
OTO - NOTNLM
OT  - asthma
OT  - cytokines
OT  - lung function test
OT  - season
OT  - vitamin D
EDAT- 2018/03/31 06:00
MHDA- 2018/03/31 06:01
PMCR- 2018/02/01
CRDT- 2018/03/31 06:00
PHST- 2016/09/06 00:00 [received]
PHST- 2016/12/18 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/03/31 06:01 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 30996 [pii]
AID - 10.5114/ada.2017.71421 [doi]
PST - ppublish
SO  - Postepy Dermatol Alergol. 2018 Feb;35(1):99-105. doi: 10.5114/ada.2017.71421. 
      Epub 2018 Feb 20.