PMID- 29599896
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20181114
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2018
DP  - 2018
TI  - Myeloid Heme Oxygenase-1 Regulates the Acute Inflammatory Response to Zymosan in 
      the Mouse Air Pouch.
PG  - 5053091
LID - 10.1155/2018/5053091 [doi]
LID - 5053091
AB  - Heme oxygenase-1 (HO-1) is induced by many stimuli to modulate the activation and 
      function of different cell types during innate immune responses. Although HO-1 
      has shown anti-inflammatory effects in different systems, there are few data on 
      the contribution of myeloid HO-1 and its role in inflammatory processes is not 
      well understood. To address this point, we have used HO-1(M-KO) mice with 
      myeloid-restricted deletion of HO-1 to specifically investigate its influence on 
      the acute inflammatory response to zymosan in vivo. In the mouse air pouch model, 
      we have shown an exacerbated inflammation in HO-1(M-KO) mice with increased 
      neutrophil infiltration accompanied by high levels of inflammatory mediators such 
      as interleukin-1beta, tumor necrosis factor-alpha, and prostaglandin E(2). The 
      expression of the degradative enzyme matrix metalloproteinase-3 (MMP-3) was also 
      enhanced. In addition, we observed higher levels of serum MMP-3 in HO-1(M-KO) 
      mice compared with control mice, suggesting the presence of systemic 
      inflammation. Altogether, these findings demonstrate that myeloid HO-1 plays an 
      anti-inflammatory role in the acute response to zymosan in vivo and suggest the 
      interest of this target to regulate inflammatory processes.
FAU - Brines, Rita
AU  - Brines R
AD  - Instituto Interuniversitario de Investigacion de Reconocimiento Molecular y 
      Desarrollo Tecnologico (IDM), Universitat Politecnica de Valencia, Universitat de 
      Valencia, Av. Vicent A. Estelles, s/n, Burjassot, 46100 Valencia, Spain.
FAU - Catalan, Laura
AU  - Catalan L
AD  - Instituto Interuniversitario de Investigacion de Reconocimiento Molecular y 
      Desarrollo Tecnologico (IDM), Universitat Politecnica de Valencia, Universitat de 
      Valencia, Av. Vicent A. Estelles, s/n, Burjassot, 46100 Valencia, Spain.
FAU - Alcaraz, Maria Jose
AU  - Alcaraz MJ
AUID- ORCID: 0000-0002-5459-6407
AD  - Instituto Interuniversitario de Investigacion de Reconocimiento Molecular y 
      Desarrollo Tecnologico (IDM), Universitat Politecnica de Valencia, Universitat de 
      Valencia, Av. Vicent A. Estelles, s/n, Burjassot, 46100 Valencia, Spain.
FAU - Ferrandiz, Maria Luisa
AU  - Ferrandiz ML
AUID- ORCID: 0000-0003-4059-0175
AD  - Instituto Interuniversitario de Investigacion de Reconocimiento Molecular y 
      Desarrollo Tecnologico (IDM), Universitat Politecnica de Valencia, Universitat de 
      Valencia, Av. Vicent A. Estelles, s/n, Burjassot, 46100 Valencia, Spain.
LA  - eng
PT  - Journal Article
DEP - 20180211
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Membrane Proteins)
RN  - 9010-72-4 (Zymosan)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 1.14.14.18 (Hmox1 protein, mouse)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Disease Models, Animal
MH  - Heme Oxygenase-1/deficiency/immunology/*metabolism
MH  - Inflammation/chemically induced/*enzymology/immunology
MH  - Macrophages, Peritoneal/enzymology/immunology
MH  - Male
MH  - Matrix Metalloproteinase 3/blood/metabolism
MH  - Membrane Proteins/deficiency/immunology/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Neutrophils/enzymology/immunology
MH  - Zymosan/toxicity
PMC - PMC5828097
EDAT- 2018/03/31 06:00
MHDA- 2018/09/06 06:00
PMCR- 2018/02/11
CRDT- 2018/03/31 06:00
PHST- 2017/06/29 00:00 [received]
PHST- 2018/01/03 00:00 [revised]
PHST- 2018/01/11 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2018/02/11 00:00 [pmc-release]
AID - 10.1155/2018/5053091 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2018 Feb 11;2018:5053091. doi: 10.1155/2018/5053091. 
      eCollection 2018.