PMID- 29600503
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 9
IP  - 3
DP  - 2018 Jun
TI  - Reproducibility and Validity of a Questionnaire Measuring Treatment Burden on 
      Patients with Type 2 Diabetes: Diabetic Treatment Burden Questionnaire (DTBQ).
PG  - 1001-1019
LID - 10.1007/s13300-018-0414-4 [doi]
AB  - INTRODUCTION: To measure the burden of pharmacotherapy on patients with type 2 
      diabetes mellitus (T2DM), we developed the Diabetes Treatment Burden 
      Questionnaire (DTBQ), a patient-administered questionnaire composed of 18 
      questions, and evaluated its reproducibility and validity. METHODS: We enrolled 
      240 patients with T2DM under pharmacotherapy over 20 years of age at seven 
      institutes in Japan. Their physicians filled out report forms on patient 
      backgrounds, and the patients answered both the DTBQ and the Diabetes Treatment 
      Satisfaction Questionnaire (DTSQ). For evaluation of reproducibility, 48 of the 
      enrolled subjects completed a 2nd DTBQ at home after leaving the medical 
      institutes. RESULTS: Statistical analyses were performed for two sets of 
      subjects, the validity analysis set (N = 236) and the reproducibility analysis 
      set (N = 47). Factor analysis found a simple structure in the DTBQ item scores 
      using a three-factor model with varimax rotation; the three subscales were 
      designated as "implementation burden", "flexibility burden", and "blood glucose 
      control burden". All intraclass correlation coefficients for the subscale scores 
      were 0.8 or higher, indicating high reproducibility. Negative correlations were 
      observed between the DTSQ satisfaction score and the DTBQ subscale scores. 
      Moreover, as the dosing frequency of diabetic medicines increased, the DTBQ total 
      score (total burden score) also became higher. Likewise, expected associations 
      were observed between patient backgrounds and DTSQ scores. CONCLUSION: The DTBQ 
      has adequate reproducibility and validity as a measurement scale for treatment 
      burden on T2DM patients. TRIAL REGISTRATION: University Hospital Medical 
      Information Network (UMIN) 000026382. FUNDING: Eli Lilly Japan.
FAU - Ishii, Hitoshi
AU  - Ishii H
AUID- ORCID: 0000-0002-6214-0557
AD  - Department of Diabetology, Nara Medical University, Nara, Japan. 
      hits1@naramed-u.ac.jp.
FAU - Shin, Koki
AU  - Shin K
AD  - Shin Clinic, Tokyo, Japan.
FAU - Tosaki, Takahiro
AU  - Tosaki T
AD  - TDE Healthcare Corporation TOSAKI Clinic for Diabetes and Endocrinology, Aichi, 
      Japan.
FAU - Haga, Tatsuya
AU  - Haga T
AD  - Haga Diabetes Clinic, Aichi, Japan.
FAU - Nakajima, Yoshiki
AU  - Nakajima Y
AD  - Nakajima Diabetes Clinic, Osaka, Japan.
FAU - Shiraiwa, Toshihiko
AU  - Shiraiwa T
AD  - Shiraiwa Medical Clinic, Osaka, Japan.
FAU - Watanabe, Nobuaki
AU  - Watanabe N
AD  - Watanabe Medical Clinic, Hyogo, Japan.
FAU - Koizumi, Miyuki
AU  - Koizumi M
AD  - Department of Diabetology, Nara Medical University, Nara, Japan.
FAU - Nakajima, Hiroki
AU  - Nakajima H
AD  - Department of Diabetology, Nara Medical University, Nara, Japan.
FAU - Okada, Sadanori
AU  - Okada S
AD  - Department of Diabetology, Nara Medical University, Nara, Japan.
FAU - Mashitani, Tsuyoshi
AU  - Mashitani T
AD  - Department of Diabetology, Nara Medical University, Nara, Japan.
FAU - Mohri, Takako
AU  - Mohri T
AD  - Department of Diabetology, Nara Medical University, Nara, Japan.
FAU - Akai, Yasuhiro
AU  - Akai Y
AD  - Department of Diabetology, Nara Medical University, Nara, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180329
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
EIN - Diabetes Ther. 2018 Aug;9(4):1719. PMID: 29909478
PMC - PMC5984917
OTO - NOTNLM
OT  - Pharmacotherapy
OT  - Questionnaire
OT  - Reproducibility
OT  - Treatment burden
OT  - Type 2 diabetes mellitus
OT  - Validity
EDAT- 2018/03/31 06:00
MHDA- 2018/03/31 06:01
PMCR- 2018/03/29
CRDT- 2018/03/31 06:00
PHST- 2018/01/16 00:00 [received]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2018/03/31 06:01 [medline]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/29 00:00 [pmc-release]
AID - 10.1007/s13300-018-0414-4 [pii]
AID - 414 [pii]
AID - 10.1007/s13300-018-0414-4 [doi]
PST - ppublish
SO  - Diabetes Ther. 2018 Jun;9(3):1001-1019. doi: 10.1007/s13300-018-0414-4. Epub 2018 
      Mar 29.