PMID- 29600726
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1552-6844 (Electronic)
IS  - 1545-9683 (Linking)
VI  - 32
IP  - 3
DP  - 2018 Mar
TI  - Aerobic With Resistance Training or Aerobic Training Alone Poststroke: A 
      Secondary Analysis From a Randomized Clinical Trial.
PG  - 209-222
LID - 10.1177/1545968318765692 [doi]
AB  - BACKGROUND: Stroke is associated with muscle atrophy and weakness, mobility 
      deficits, and cardiorespiratory deconditioning. Aerobic and resistance training 
      (AT and RT) each have the potential to improve deficits, yet there is limited 
      evidence on the utility of combined training. OBJECTIVE: To examine the effects 
      of AT+RT versus AT on physiological outcomes in chronic stroke with motor 
      impairments. METHODS: Participants (n = 73) were randomized to 6 months of AT (5 
      d/wk) or AT+RT (3 and 2 d/wk, respectively). Outcomes included those related to 
      body composition by dual-energy X-ray absorptiometry, mobility (6-minute walk 
      distance [6MWD], sit-to-stand, and stair climb performance), cardiorespiratory 
      fitness (VO(2peak), oxygen uptake at the ventilatory threshold [VO(2VT)]), and 
      muscular strength. RESULTS: A total of 68 (93.2%) participants (age, mean +/- SD = 
      63.7 +/- 11.9) completed the study. AT+RT and AT yielded similar and significant 
      improvements in 6MWD (39.9 +/- 55.6 vs 36.5 +/- 63.7 m, P = .8), VO(2peak) (16.4% +/- 
      43.8% vs 15.2% +/- 24.7%, P = .9), sit-to-stand time (-2.3 +/- 5.1 vs 1.02 +/- 9.5 s, P 
      = .05), and stair climb performance (8.2% +/- 19.6% vs 7.5% +/- 23%, P = .97), 
      respectively. AT+RT produced greater improvements than AT alone for total body 
      lean mass (1.23 +/- 2.3 vs 0.27 +/- 1.6 kg, P = .039), predominantly trunk ( P = .02) 
      and affected-side limbs ( P = .04), VO(2VT) (19.1% +/- 26.8% vs 10.5% +/- 28.9%, P = 
      .046), and upper- and lower-limb muscular strength ( P < .03, all except 
      affected-side leg). CONCLUSION: Despite being prescribed 40% less AT, AT+RT 
      resulted in similar and significant improvement in mobility and VO(2peak), 
      superior improvements in VO(2VT) and muscular strength, and an almost 5-fold 
      greater increase in lean mass compared with AT. RT is the most neglected exercise 
      component following stroke but should be prescribed with AT for metabolic, 
      cardiorespiratory, and strength recovery.
FAU - Marzolini, Susan
AU  - Marzolini S
AUID- ORCID: 0000-0002-3186-400X
AD  - 1 Toronto Rehab-University Health Network, Toronto, ON, Canada.
AD  - 2 University of Toronto, Toronto, ON, Canada.
AD  - 3 Canadian Partnership for Stroke Recovery.
FAU - Brooks, Dina
AU  - Brooks D
AD  - 1 Toronto Rehab-University Health Network, Toronto, ON, Canada.
AD  - 2 University of Toronto, Toronto, ON, Canada.
AD  - 3 Canadian Partnership for Stroke Recovery.
FAU - Oh, Paul
AU  - Oh P
AD  - 1 Toronto Rehab-University Health Network, Toronto, ON, Canada.
AD  - 3 Canadian Partnership for Stroke Recovery.
FAU - Jagroop, David
AU  - Jagroop D
AD  - 1 Toronto Rehab-University Health Network, Toronto, ON, Canada.
AD  - 4 University of Ontario Institute of Technology, Oshawa, ON, Canada.
FAU - MacIntosh, Bradley J
AU  - MacIntosh BJ
AD  - 3 Canadian Partnership for Stroke Recovery.
AD  - 5 Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
FAU - Anderson, Nicole D
AU  - Anderson ND
AD  - 2 University of Toronto, Toronto, ON, Canada.
AD  - 3 Canadian Partnership for Stroke Recovery.
AD  - 6 Rotman Research Institute, Baycrest Health Sciences, Toronto, ON.
FAU - Alter, David
AU  - Alter D
AD  - 1 Toronto Rehab-University Health Network, Toronto, ON, Canada.
AD  - 7 Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.
FAU - Corbett, Dale
AU  - Corbett D
AD  - 3 Canadian Partnership for Stroke Recovery.
AD  - 8 University of Ottawa, Ottawa, Canada.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180330
PL  - United States
TA  - Neurorehabil Neural Repair
JT  - Neurorehabilitation and neural repair
JID - 100892086
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Composition/physiology
MH  - Cardiorespiratory Fitness/physiology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength/physiology
MH  - *Resistance Training
MH  - Stroke/*physiopathology
MH  - Stroke Rehabilitation/*methods
MH  - Treatment Outcome
MH  - Walking/physiology
OTO - NOTNLM
OT  - aerobic exercise
OT  - body composition
OT  - cardiorespiratory fitness
OT  - exercise
OT  - resistance training
EDAT- 2018/03/31 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/03/31 06:00
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/03/31 06:00 [entrez]
AID - 10.1177/1545968318765692 [doi]
PST - ppublish
SO  - Neurorehabil Neural Repair. 2018 Mar;32(3):209-222. doi: 
      10.1177/1545968318765692. Epub 2018 Mar 30.