PMID- 29600786
OWN - NLM
STAT- MEDLINE
DCOM- 20191008
LR  - 20220408
IS  - 2405-5018 (Electronic)
IS  - 2405-500X (Linking)
VI  - 4
IP  - 1
DP  - 2018 Jan
TI  - The Spatial Distribution of Late Gadolinium Enhancement of Left Atrial Magnetic 
      Resonance Imaging in Patients With Atrial Fibrillation.
PG  - 49-58
LID - S2405-500X(17)30612-6 [pii]
LID - 10.1016/j.jacep.2017.07.016 [doi]
AB  - OBJECTIVES: The purpose of this study is to evaluate the spatial distribution of 
      late gadolinium enhancement (LGE) of the left atrium (LA) by LGE-magnetic 
      resonance imaging in an atrial fibrillation (AF) population. BACKGROUND: LGE of 
      the LA can be a surrogate of pre-existing structural remodeling of LA. METHODS: 
      LGE-magnetic resonance imaging scans were used for 160 patients with AF (mean age 
      66 +/- 11 years) before AF ablation. To know the spatial distribution of LGE, the 
      extent of LGE in 6 LA subregions was examined. Overall LGE distribution was also 
      summarized as a spatial frequency histogram using an atlas of LA shape. These 
      data were also compared between paroxysmal AF (87 patients) and persistent AF (73 
      patients). RESULTS: LGE coverage (%) in each subregion was as follows: 41.8 +/- 
      18.9% in the left pulmonary vein (PV) antrum, 27.1 +/- 16.7% in the left lateral 
      wall, 25.8 +/- 15.3% in the posterior wall, 19.7 +/- 15.3% in the anterior wall, 17.1 
      +/- 15.0% in the right PV antrum, and 12.0 +/- 13.2% in the septum wall. LGE was 
      heterogeneously distributed in the LA and was found with the highest frequency in 
      the posterior wall near the inferior left PV antrum by the LGE histogram. A 
      comparison of paroxysmal AF with persistent AF suggests that LGE was more 
      expected in persistent AF compared with paroxysmal AF, particularly with a spread 
      on the posterior and the anterior wall. CONCLUSIONS: LGE in the LA was 
      heterogeneously distributed. LGE was highly distributed in the inferior 
      left PV antrum near the posterior wall side, and spread on the posterior and 
      anterior wall with AF progression.
CI  - Copyright (c) 2018 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Higuchi, Koji
AU  - Higuchi K
AD  - Comprehensive Arrhythmia and Research Management (CARMA) Center, University of 
      Utah School of Medicine, Salt Lake City, Utah.
FAU - Cates, Joshua
AU  - Cates J
AD  - Comprehensive Arrhythmia and Research Management (CARMA) Center, University of 
      Utah School of Medicine, Salt Lake City, Utah.
FAU - Gardner, Gregory
AU  - Gardner G
AD  - Comprehensive Arrhythmia and Research Management (CARMA) Center, University of 
      Utah School of Medicine, Salt Lake City, Utah.
FAU - Morris, Alan
AU  - Morris A
AD  - Comprehensive Arrhythmia and Research Management (CARMA) Center, University of 
      Utah School of Medicine, Salt Lake City, Utah.
FAU - Burgon, Nathan S
AU  - Burgon NS
AD  - Comprehensive Arrhythmia and Research Management (CARMA) Center, University of 
      Utah School of Medicine, Salt Lake City, Utah.
FAU - Akoum, Nazem
AU  - Akoum N
AD  - Comprehensive Arrhythmia and Research Management (CARMA) Center, University of 
      Utah School of Medicine, Salt Lake City, Utah.
FAU - Marrouche, Nassir F
AU  - Marrouche NF
AD  - Comprehensive Arrhythmia and Research Management (CARMA) Center, University of 
      Utah School of Medicine, Salt Lake City, Utah. Electronic address: 
      Nassir.Marrouche@hsc.utah.edu.
LA  - eng
PT  - Journal Article
DEP - 20170927
PL  - United States
TA  - JACC Clin Electrophysiol
JT  - JACC. Clinical electrophysiology
JID - 101656995
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - *Atrial Fibrillation/diagnostic imaging/metabolism
MH  - Atrial Remodeling
MH  - Contrast Media/administration & dosage/*pharmacokinetics/therapeutic use
MH  - Female
MH  - Gadolinium/administration & dosage/*pharmacokinetics/therapeutic use
MH  - *Heart Atria/diagnostic imaging/metabolism
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Tissue Distribution
OTO - NOTNLM
OT  - LGE-MR
OT  - atrial fibrillation
OT  - remodeling
OT  - spatial distribution
EDAT- 2018/03/31 06:00
MHDA- 2019/10/09 06:00
CRDT- 2018/03/31 06:00
PHST- 2017/03/24 00:00 [received]
PHST- 2017/07/03 00:00 [revised]
PHST- 2017/07/06 00:00 [accepted]
PHST- 2018/03/31 06:00 [entrez]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2019/10/09 06:00 [medline]
AID - S2405-500X(17)30612-6 [pii]
AID - 10.1016/j.jacep.2017.07.016 [doi]
PST - ppublish
SO  - JACC Clin Electrophysiol. 2018 Jan;4(1):49-58. doi: 10.1016/j.jacep.2017.07.016. 
      Epub 2017 Sep 27.