PMID- 29601139 OWN - NLM STAT- MEDLINE DCOM- 20190930 LR - 20190930 IS - 1522-2586 (Electronic) IS - 1053-1807 (Linking) VI - 48 IP - 4 DP - 2018 Oct TI - Myocardial fibrosis evaluated by diffusion-weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy. PG - 1139-1146 LID - 10.1002/jmri.26016 [doi] AB - BACKGROUND: Previous studies have shown that diffusion-weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy. PURPOSE: To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the contractile function in hypertrophic cardiomyopathy (HCM). STUDY TYPE: Prospective. POPULATION: A total of 45 HCM patients and 20 controls. FIELD STRENGTH/SEQUENCE: 3.0T cardiac MRI. The cardiac MR sequences included cine, T(1) mapping, and DWI. ASSESSMENT: According to the presence of late gadolinium enhancement (LGE) and the extracellular volume (ECV) values (+2 SD of control subjects), respectively, reader W and reader J assessed the value of ADC of each segment for detecting myocardial fibrosis and its relationship to impaired contractile function in HCM patients. STATISTICAL TESTS: Independent sample t-test, Pearson analysis, and intraclass correlation (ICC). RESULTS: The value of ECV was 23.6 +/- 3.0% for control. ECV >/= 29.6% and ECV < 29.6% groups were classified. ADC values in the ECV >/= 29.6% group were significantly increased compared to the ECV < 29.6% group, (2.41 +/- 0.23 mum(2) /ms vs. 2.03 +/- 0.16 mum(2) /ms, P < 0.005). Compared to the LGE - group, ECV (32.1 +/- 2.3% vs. 29.0 +/- 2.8%, P < 0.005) and ADC (2.60 +/- 0.18 mum(2) /ms vs. 2.10 +/- 0.07 mum(2) /ms, P < 0.005) values were significantly increased in the LGE + group. ADC values were linearly associated with ECV values (R(2) = 0.65) in HCM patients. ADC values were linearly associated with circumferential and longitudinal strain (R(2) = 0.60, R(2) = 0.46), as well as circumferential, longitudinal, and radial strain rate (R(2) = 0.13, R(2) = 0.25, R(2) = 0.17, respectively). DATA CONCLUSION: Contractile dysfunction in HCM is predominantly associated with ADC, which is a feasible alternative to ECV and LGE for detecting myocardial fibrosis. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1139-1146. CI - (c) 2018 International Society for Magnetic Resonance in Medicine. FAU - Wu, Rui AU - Wu R AD - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - An, Dong-Aolei AU - An DA AD - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Shi, Ruo-Yang AU - Shi RY AD - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Chen, Bing-Hua AU - Chen BH AUID- ORCID: 0000-0002-2718-8416 AD - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Jiang, Meng AU - Jiang M AD - Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Bacyinski, Andrew AU - Bacyinski A AD - Department of Physical Medicine and Rehabilitation, Detroit Medical Center, Detroit, Michigan, USA. FAU - Han, Tong-Tong AU - Han TT AD - Circle Cardiovascular Imaging Inc., Calgary, AB, Canada. FAU - Hu, Jiani AU - Hu J AD - Department of Radiology, Wayne State University, Detroit, Michigan, USA. FAU - Xu, Jian-Rong AU - Xu JR AD - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Wu, Lian-Ming AU - Wu LM AD - Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. LA - eng GR - Youth Program 81401403/National Natural Science Foundation of China/International GR - Young Talent Program 2017YQ031/Shanghai Municipal Commission of Health and Family Planning/International GR - Engineering Cross Fund YG2014MS48/Shanghai Jiao Tong University Medical/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180330 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Contrast Media) SB - IM MH - Adult MH - Cardiomyopathy, Hypertrophic/*diagnostic imaging MH - Contrast Media MH - *Diffusion Magnetic Resonance Imaging MH - Female MH - Fibrosis MH - Heart/*diagnostic imaging MH - Humans MH - Image Interpretation, Computer-Assisted MH - *Imaging, Three-Dimensional MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - *Myocardial Contraction MH - Myocardium/*pathology MH - Prognosis MH - Prospective Studies MH - Reproducibility of Results OTO - NOTNLM OT - DWI OT - ECV OT - HCM OT - LGE OT - apparent diffusion coefficient OT - tissue tracking EDAT- 2018/03/31 06:00 MHDA- 2019/10/01 06:00 CRDT- 2018/03/31 06:00 PHST- 2017/11/04 00:00 [received] PHST- 2018/03/02 00:00 [accepted] PHST- 2018/03/31 06:00 [pubmed] PHST- 2019/10/01 06:00 [medline] PHST- 2018/03/31 06:00 [entrez] AID - 10.1002/jmri.26016 [doi] PST - ppublish SO - J Magn Reson Imaging. 2018 Oct;48(4):1139-1146. doi: 10.1002/jmri.26016. Epub 2018 Mar 30.