PMID- 29601937
OWN - NLM
STAT- MEDLINE
DCOM- 20190103
LR  - 20190103
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 79
IP  - 2
DP  - 2018 Aug
TI  - Subungual atypical lentiginous melanocytic proliferations in children and 
      adolescents: A clinicopathologic study.
PG  - 327-336.e2
LID - S0190-9622(18)30484-5 [pii]
LID - 10.1016/j.jaad.2018.03.030 [doi]
AB  - BACKGROUND: Most subungual melanocytic lesions in children are benign, but some 
      are difficult to classify due to prominent lentiginous growth and high-grade 
      cytologic atypia. OBJECTIVE: To characterize the clinicopathologic features of 
      these rare lesions. METHODS: Subungual atypical lentiginous melanocytic 
      proliferations from patients <20 years of age were collected for clinical and 
      histopathologic review. Fluorescence in situ hybridization (FISH) was performed 
      when possible. RESULTS: Eleven patients aged 2-19 years had expanding or 
      darkening longitudinal pigmented streak(s) with or without Hutchinson sign. 
      Microscopically, all revealed predominantly single-cell growth, pagetoid scatter, 
      and poor circumscription. Eight (73%) cases showed focal or poor nesting, and 3 
      (27%) demonstrated confluence. Nuclear enlargement, hyperchromasia, and 
      angulation were present in 8 (73%) cases, 7 (64%) cases, and 6 (55%) cases, 
      respectively. One of 4 cases tested by FISH was positive. Three lesions recurred 
      locally without other adverse outcome. LIMITATIONS: Small sample size and short 
      clinical follow-up. Two cases were examined in partial biopsies only. CONCLUSION: 
      Some subungual melanocytic lesions in children and adolescents are histologically 
      indistinguishable from adult subungual melanoma in situ. While the biologic 
      potential remains elusive, FISH might aid in risk stratification. Awareness of 
      this rare group of lesions is crucial for facilitating future investigation into 
      its biologic behavior.
CI  - Copyright (c) 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. 
      All rights reserved.
FAU - Khatri, Sameer S
AU  - Khatri SS
AD  - Department of Pathology, University of Michigan, Ann Arbor, Michigan.
FAU - Wang, Min
AU  - Wang M
AD  - Department of Pathology, University of Michigan, Ann Arbor, Michigan.
FAU - Harms, Kelly L
AU  - Harms KL
AD  - Department of Dermatology, University of Michigan, Ann Arbor, Michigan.
FAU - Durham, Alison B
AU  - Durham AB
AD  - Department of Dermatology, University of Michigan, Ann Arbor, Michigan.
FAU - Johnson, Timothy M
AU  - Johnson TM
AD  - Department of Dermatology, University of Michigan, Ann Arbor, Michigan; 
      Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan; 
      Department of Surgery, University of Michigan, Ann Arbor, Michigan.
FAU - Nazarian, Rosalynn M
AU  - Nazarian RM
AD  - Pathology Service, Massachusetts General Hospital, Harvard Medical School, 
      Boston, Massachusetts.
FAU - Harms, Paul W
AU  - Harms PW
AD  - Department of Pathology, University of Michigan, Ann Arbor, Michigan; Department 
      of Dermatology, University of Michigan, Ann Arbor, Michigan.
FAU - Fullen, Douglas R
AU  - Fullen DR
AD  - Department of Pathology, University of Michigan, Ann Arbor, Michigan; Department 
      of Dermatology, University of Michigan, Ann Arbor, Michigan.
FAU - Andea, Aleodor A
AU  - Andea AA
AD  - Department of Pathology, University of Michigan, Ann Arbor, Michigan; Department 
      of Dermatology, University of Michigan, Ann Arbor, Michigan.
FAU - Chan, May P
AU  - Chan MP
AD  - Department of Pathology, University of Michigan, Ann Arbor, Michigan; Department 
      of Dermatology, University of Michigan, Ann Arbor, Michigan. Electronic address: 
      mpchan@med.umich.edu.
LA  - eng
PT  - Journal Article
DEP - 20180327
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Hutchinson's Melanotic Freckle/diagnosis/genetics/pathology/surgery
MH  - In Situ Hybridization, Fluorescence
MH  - Lentigo/diagnosis/genetics/*pathology/surgery
MH  - Male
MH  - Melanocytes/*pathology
MH  - Melanoma/diagnosis/genetics/pathology/surgery
MH  - Nail Diseases/diagnosis/genetics/*pathology/surgery
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Skin Neoplasms/diagnosis/genetics/pathology/surgery
MH  - Young Adult
OTO - NOTNLM
OT  - melanocytic hyperplasia
OT  - melanoma
OT  - melanonychia
OT  - nail
OT  - pediatric
OT  - subungual
EDAT- 2018/03/31 06:00
MHDA- 2019/01/04 06:00
CRDT- 2018/03/31 06:00
PHST- 2017/09/11 00:00 [received]
PHST- 2018/03/11 00:00 [revised]
PHST- 2018/03/14 00:00 [accepted]
PHST- 2018/03/31 06:00 [pubmed]
PHST- 2019/01/04 06:00 [medline]
PHST- 2018/03/31 06:00 [entrez]
AID - S0190-9622(18)30484-5 [pii]
AID - 10.1016/j.jaad.2018.03.030 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2018 Aug;79(2):327-336.e2. doi: 10.1016/j.jaad.2018.03.030. 
      Epub 2018 Mar 27.