PMID- 29602542
OWN - NLM
STAT- MEDLINE
DCOM- 20190620
LR  - 20220408
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 52
DP  - 2018 Jul
TI  - Decreased interhemispheric homotopic connectivity in Parkinson's disease patients 
      with freezing of gait: A resting state fMRI study.
PG  - 30-36
LID - S1353-8020(18)30130-5 [pii]
LID - 10.1016/j.parkreldis.2018.03.015 [doi]
AB  - INTRODUCTION: Freezing of gait is a common complaint in patients with Parkinson's 
      disease (PD). However, the neural bases of freezing of gait in PD remain 
      uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have 
      reported damage of the corpus callosum, the largest commissural bundle of the 
      brain. Thus, in this study we explored homotopic connectivity to investigate 
      FOG-related interehemispheric alterations METHODS: A total of 21 
      PD-FOG + patients, 33 PD patients without freezing of gait (PD-FOG-), and 24 
      matched healthy controls were recruited. All PD patients were evaluated via the 
      FOG questionnaire (FOGQ) and all subjects had a resting state functional magnetic 
      resonance imaging (rs-fMRI) scan. The pattern of the homotopic connectivity was 
      measured with the voxel-mirrored homotopic connectivity (VMHC) approach. RESULT: 
      The PD-FOG + patients showed decreased VMHC values in the inferior parietal lobe 
      (IPL) compared to both PD-FOG-patients and healthy controls. In 
      PD-FOG + patients, the mean VMHC values in the IPL were negatively correlated 
      with the FOGQ scores. Receiver operating characteristic curves analyses revealed 
      that the VMHC in the IPL had discriminatory function distinguishing 
      PD-FOG + patients from PD-FOG-patients or healthy controls. CONCLUSION: Decreased 
      VMHC values of PD-FOG + patients relative to PD-FOG- and healthy controls in IPL 
      maybe a unique feature for PD-FOG+ and it may have the ability to separate 
      PD-FOG + patients from PD-FOG- and healthy controls.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Li, Junyi
AU  - Li J
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China.
FAU - Yuan, Yongsheng
AU  - Yuan Y
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China.
FAU - Wang, Min
AU  - Wang M
AD  - Department of Radiology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China.
FAU - Zhang, Jiejin
AU  - Zhang J
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China.
FAU - Jiang, Siming
AU  - Jiang S
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China.
FAU - Wang, Xixi
AU  - Wang X
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China.
FAU - Ding, Jian
AU  - Ding J
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China.
FAU - Zhang, Kezhong
AU  - Zhang K
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, No. 300 Guangzhou Road, Nanjing 210029, China. Electronic address: 
      kezhong_zhang1969@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180326
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Brain Mapping
MH  - Corpus Callosum/*diagnostic imaging
MH  - Female
MH  - Gait Disorders, Neurologic/complications/*diagnostic imaging
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/diagnostic imaging
MH  - Oxygen/blood
MH  - Parkinson Disease/complications/*diagnostic imaging
MH  - *Rest
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Freezing of gait
OT  - Parkinson's disease
OT  - Resting-state fMRI
OT  - Voxel-mirrored homotopic connectivity
EDAT- 2018/04/01 06:00
MHDA- 2019/06/21 06:00
CRDT- 2018/04/01 06:00
PHST- 2017/05/18 00:00 [received]
PHST- 2018/02/18 00:00 [revised]
PHST- 2018/03/14 00:00 [accepted]
PHST- 2018/04/01 06:00 [pubmed]
PHST- 2019/06/21 06:00 [medline]
PHST- 2018/04/01 06:00 [entrez]
AID - S1353-8020(18)30130-5 [pii]
AID - 10.1016/j.parkreldis.2018.03.015 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2018 Jul;52:30-36. doi: 
      10.1016/j.parkreldis.2018.03.015. Epub 2018 Mar 26.