PMID- 29602562
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20190903
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 178
DP  - 2018 Sep
TI  - Design of drug delivery systems for physical energy-induced chemical surgery.
PG  - 583-596
LID - S0142-9612(18)30211-4 [pii]
LID - 10.1016/j.biomaterials.2018.03.038 [doi]
AB  - Physical energy-induced chemical surgery, a technique that induces antitumor 
      effects by delivering a drug that exerts a therapeutic effect in response to 
      physical energy and irradiating the diseased part with the corresponding physical 
      energy, is a useful method to treat cancers with minimal systemic side effects. 
      Among chemical surgery, photodynamic therapy (PDT) and neutron capture therapy 
      (NCT) require a system that selectively delivers drugs to the diseased site. 
      Although PDT and NCT have a similar concept, drug delivery systems (DDSs) for 
      their purpose need different functions to solve the unique problems derived from 
      the characteristics of respective physical energy. In this review, we will 
      describe recent chemistry-based solutions including ours to overcome these 
      challenges.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Nomoto, Takahiro
AU  - Nomoto T
AD  - Laboratory for Chemistry and Life Science, Institute of Innovative Research, 
      Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa, 
      226-8503, Japan.
FAU - Nishiyama, Nobuhiro
AU  - Nishiyama N
AD  - Laboratory for Chemistry and Life Science, Institute of Innovative Research, 
      Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa, 
      226-8503, Japan. Electronic address: nishiyama.n.ad@m.titech.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180322
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Micelles)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Micelles
MH  - *Neutron Capture Therapy
MH  - *Photochemotherapy
OTO - NOTNLM
OT  - Companion diagnostics
OT  - Drug delivery system
OT  - Neutron capture therapy
OT  - Photochemical internalization
OT  - Photodynamic therapy
EDAT- 2018/04/01 06:00
MHDA- 2019/09/04 06:00
CRDT- 2018/04/01 06:00
PHST- 2018/01/22 00:00 [received]
PHST- 2018/03/17 00:00 [revised]
PHST- 2018/03/22 00:00 [accepted]
PHST- 2018/04/01 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2018/04/01 06:00 [entrez]
AID - S0142-9612(18)30211-4 [pii]
AID - 10.1016/j.biomaterials.2018.03.038 [doi]
PST - ppublish
SO  - Biomaterials. 2018 Sep;178:583-596. doi: 10.1016/j.biomaterials.2018.03.038. Epub 
      2018 Mar 22.