PMID- 29603712
OWN - NLM
STAT- MEDLINE
DCOM- 20180906
LR  - 20190606
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 24
DP  - 2018 Mar 31
TI  - A Retrospective Study to Compare the Use of the Mean Apnea-Hypopnea Duration and 
      the Apnea-Hypopnea Index with Blood Oxygenation and Sleep Patterns in Patients 
      with Obstructive Sleep Apnea Diagnosed by Polysomnography.
PG  - 1887-1893
AB  - BACKGROUND The apnea-hypopnea index (AHI) and the mean apnea-hypopnea duration 
      (MAD) are used to measure the severity of the symptoms of obstructive sleep apnea 
      (OSA). The aim of this study was to compare the use of the MAD with the AHI as 
      indicators of clinical and demographic parameters, blood oxygenation, and sleep 
      parameters in patients diagnosed with OSA by polysomnography (PSG). MATERIAL AND 
      METHODS A retrospective study included 511 patients with OSA diagnosed by PSG and 
      who had the AHI and the MAD measured according to the guidelines from the 
      American Academy of Sleep Medicine (AASM). The patients were divided into two 
      groups: patients with a short MAD and with a long MAD, according to median 
      duration, and using the inter-quartile range (IQR), as the data were not normally 
      distributed. Clinical and demographic parameters were recorded. Pulse oximetry 
      was used to measure blood oxygen saturation during sleep, sleep structure was 
      recorded, and the Epworth Sleepiness Scale (ESS) questionnaire was used to 
      measure daytime sleepiness. RESULTS In all 511 patients with OSA, the MAD was 
      significantly, but weakly, correlated with the AHI (r=0.17, P<0.01), but showed 
      no significant associations with patient age (r=0.08, P=0.06), body weight 
      (r=0.014, P=0.75), and height (r=0.06, P=0.16). Patients with a long MAD or 
      severe OSA (n=260) had significantly worse blood oxygen levels and sleep 
      parameters. CONCLUSIONS For patients with severe OSA, this study showed that the 
      MAD was a useful indicator of blood oxygenation and sleep parameters.
FAU - Zhan, Xiaojun
AU  - Zhan X
AD  - Department of Otolaryngology, Head and Neck Surgery, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China (mainland).
FAU - Fang, Fang
AU  - Fang F
AD  - Sleep Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China 
      (mainland).
FAU - Wu, Chan
AU  - Wu C
AD  - Department of Otolaryngology, Head and Neck Surgery, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China (mainland).
FAU - Pinto, Jayant M
AU  - Pinto JM
AD  - Section of Otolaryngology, Head and Neck Surgery, Department of Surgery, The 
      University of Chicago, Chicago, IL, USA.
FAU - Wei, Yongxiang
AU  - Wei Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China (mainland).
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180331
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apnea/blood/*metabolism
MH  - Blood Pressure/physiology
MH  - Female
MH  - Humans
MH  - Hypertension/complications
MH  - Hypoxia/metabolism
MH  - Male
MH  - Middle Aged
MH  - Oximetry/methods
MH  - Oxygen/blood
MH  - Polysomnography/methods
MH  - Respiratory Rate
MH  - Retrospective Studies
MH  - Sleep/physiology
MH  - Sleep Apnea Syndromes/blood/*metabolism
MH  - Sleep Apnea, Obstructive/*complications
MH  - Sleep Stages/physiology
PMC - PMC5892846
COIS- Conflict of interest None.
EDAT- 2018/04/01 06:00
MHDA- 2018/09/07 06:00
PMCR- 2018/03/31
CRDT- 2018/04/01 06:00
PHST- 2018/04/01 06:00 [entrez]
PHST- 2018/04/01 06:00 [pubmed]
PHST- 2018/09/07 06:00 [medline]
PHST- 2018/03/31 00:00 [pmc-release]
AID - 909219 [pii]
AID - 10.12659/msm.909219 [doi]
PST - epublish
SO  - Med Sci Monit. 2018 Mar 31;24:1887-1893. doi: 10.12659/msm.909219.