PMID- 29604268
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20180521
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 202
DP  - 2018 Jun 1
TI  - Mild aerobic training with blood flow restriction increases the hypertrophy index 
      and MuSK in both slow and fast muscles of old rats: Role of PGC-1alpha.
PG  - 103-109
LID - S0024-3205(18)30165-6 [pii]
LID - 10.1016/j.lfs.2018.03.051 [doi]
AB  - AIMS: Existing evidence emphasize the role of mitochondrial dysfunction in 
      sarcopenia which is revealed as loss of skeletal muscle mass and neuromuscular 
      junction remodeling. We assessed the effect of low-intensity aerobic training 
      along with blood flow restriction on muscle hypertrophy index, muscle-specific 
      kinase (MuSK), a pivotal protein of the neuromuscular junction and Peroxisome 
      proliferator-activated receptor gamma co-activator 1-alpha (PGC-1alpha) in aged male 
      rats. MAIN METHODS: Animals groups were control (CTL), sham (Sh), leg blood flow 
      restriction (BFR), exercise (Ex), sham + exercise (Sh + Ex), and BFR plus 
      exercise (BFR + Ex) groups. The exercise groups were trained with low intensity 
      exercise for 10 weeks. 48 h after the last training session, animals were 
      sacrificed under anesthesia. Soleus and EDL muscles were isolated, hypertrophy 
      index was estimated and MuSK and PGC-1alpha were measured by western blot method. KEY 
      FINDINGS: Hypertrophy index enhanced in soleus and Extensor digitorum longus 
      (EDL) muscles of BFR + Ex group (P < 0.01 versus CTL and Sh groups, and P < 0.001 
      versus other groups). The MuSK protein of soleus and EDL muscles increased in 
      BFR + Ex group (P < 0.01 and P < 0.001, respectively) in comparison with CTL and 
      Sh groups. In BFR + Ex group, the PGC-1alpha protein increased in both soleus and EDL 
      (P < 0.001 compared to other groups). Also the PGC-1alpha of soleus muscle was higher 
      in Ex and Sh + Ex groups versus CTL and Sh groups (P < 0.05). SIGNIFICANCE: 
      Findings suggest that low endurance exercise plus BFR improves the MuSK and 
      hypertrophy index of both slow and fast muscles of elderly rats probably through 
      the rise of PGC-1alpha expression.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Bahreinipour, Mohammad-Ali
AU  - Bahreinipour MA
AD  - Department of Physical Education, Faculty of Shahid Chamran, Kerman Branch, 
      Technical and Vocational University (YVU), Tehran, Iran.
FAU - Joukar, Siyavash
AU  - Joukar S
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran; Physiology Research Center, Institute of 
      Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; 
      Cardiovascular Research Center, Institute of Basic and Clinical Physiology 
      Sciences, Kerman University of Medical Science, Kerman, Iran; Department of 
      Physiology and Pharmacology, School of Medicine, Kerman University of Medical 
      Sciences, Kerman, Iran. Electronic address: jokar@kmu.ac.ir.
FAU - Hovanloo, Fariborz
AU  - Hovanloo F
AD  - Physical Education and Sport Science College, Shahid Beheshti University, Tehran, 
      Iran.
FAU - Najafipour, Hamid
AU  - Najafipour H
AD  - Cardiovascular Research Center, Institute of Basic and Clinical Physiology 
      Sciences, Kerman University of Medical Science, Kerman, Iran; Department of 
      Physiology and Pharmacology, School of Medicine, Kerman University of Medical 
      Sciences, Kerman, Iran.
FAU - Naderi, Vida
AU  - Naderi V
AD  - Physiology Research Center, Institute of Neuropharmacology, Kerman University of 
      Medical Sciences, Kerman, Iran.
FAU - Rajiamirhasani, Alireza
AU  - Rajiamirhasani A
AD  - Physiology Research Center, Institute of Neuropharmacology, Kerman University of 
      Medical Sciences, Kerman, Iran.
FAU - Esmaeili-Mahani, Saeed
AU  - Esmaeili-Mahani S
AD  - Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, 
      Kerman, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180328
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, rat)
RN  - EC 2.7.10.1 (MuSK protein, mouse)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Aerobiosis
MH  - Aging/physiology
MH  - Animals
MH  - Hindlimb/blood supply
MH  - Hypertrophy
MH  - Male
MH  - Muscle Contraction/physiology
MH  - Muscle Fibers, Fast-Twitch/*metabolism
MH  - Muscle Fibers, Slow-Twitch/*metabolism
MH  - Muscle, Skeletal/*blood supply/*growth & development/metabolism
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 
      1-alpha/genetics/*physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/*biosynthesis/genetics
MH  - Regional Blood Flow
OTO - NOTNLM
OT  - Aerobic training
OT  - Aging
OT  - Blood flow restriction
OT  - Hypertrophy index
OT  - MuSK
OT  - PGC-1alpha
EDAT- 2018/04/01 06:00
MHDA- 2018/05/22 06:00
CRDT- 2018/04/01 06:00
PHST- 2017/10/14 00:00 [received]
PHST- 2018/02/24 00:00 [revised]
PHST- 2018/03/26 00:00 [accepted]
PHST- 2018/04/01 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2018/04/01 06:00 [entrez]
AID - S0024-3205(18)30165-6 [pii]
AID - 10.1016/j.lfs.2018.03.051 [doi]
PST - ppublish
SO  - Life Sci. 2018 Jun 1;202:103-109. doi: 10.1016/j.lfs.2018.03.051. Epub 2018 Mar 
      28.