PMID- 29604593
OWN - NLM
STAT- MEDLINE
DCOM- 20181002
LR  - 20211204
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 102
DP  - 2018 Jun
TI  - Ebselen can Protect Male Reproductive Organs and Male Fertility from Manganese 
      Toxicity: Structural and Bioanalytical Approach in a Rat Model.
PG  - 739-748
LID - S0753-3322(17)36212-1 [pii]
LID - 10.1016/j.biopha.2018.03.086 [doi]
AB  - Ebselen (EBS) is a versatile compound that can protect the cellular components 
      from oxidative and free radical-mediated damage. In the present study, we 
      investigated the protective effect of EBS against manganese (Mn) toxicity on male 
      reproductive organs. Thirty-two male rats were assigned into four groups, namely, 
      negative control, EBS (15 mg/kg body weight (bw), as a single protective IP 
      injection), MnCl(2) (50 mg/kg bw, orally for 30 consecutive days), and 
      EBS + MnCl(2) (as mentioned before). The results showed that EBS ameliorated the 
      alterations caused by MnCl(2) in the testicular, epididymal, and seminal vesicle 
      tissues. MnCl(2) increased the sperm abnormalities, decreased gonadosomatic index 
      (GSI), sperm motility, and sperm count. Further, it reduced the serum levels of 
      testosterone (T) and luteinizing hormone (LH). The elevated levels of 
      malondialdehyde (MDA), nitric oxide (NO), and 8-OH-2'-deoxyguanosine (8-OHdG) and 
      decreased the levels of superoxide dismutase (SOD), glutathione (GSH), and 
      catalase (CAT) upon exposure to MnCl(2) indicated a disturbance in the activities 
      of the testicular antioxidant enzymes and indices. Histologically, MnCl(2) 
      decreased the diameter of seminiferous tubules (ST), the height of germinal 
      epithelium, number of spermatogonia/ST, spermatocytes/ST, spermatids/ST, and 
      Leydig cells/intertubular area (IA). Chemoprotection with EBS successfully 
      mitigated most of the above-mentioned parameters concluding that EBS could be 
      used as a useful prophylactic therapy whenever Mn toxicity is involved.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Mohammed, Amany Tharwat
AU  - Mohammed AT
AD  - Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, 
      Zagazig University, Zagazig, 44511, Egypt. Electronic address: 
      atkhalil@zu.edu.eg.
FAU - Ebraheim, Lamiaa L M
AU  - Ebraheim LLM
AD  - Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig 
      University, Zagazig, 44511, Egypt.
FAU - Metwally, Mohamed M M
AU  - Metwally MMM
AD  - Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, 
      Zagazig, 44511, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20180405
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antioxidants)
RN  - 0 (Azoles)
RN  - 0 (Hormones)
RN  - 0 (Isoindoles)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (Protective Agents)
RN  - 40X2P7DPGH (ebselen)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Azoles/*chemistry/*pharmacology
MH  - Body Weight/drug effects
MH  - Epididymis/drug effects
MH  - Fertility/*drug effects
MH  - Genitalia, Male/drug effects/*pathology/ultrastructure
MH  - Hormones/blood
MH  - Isoindoles
MH  - Male
MH  - Manganese/*toxicity
MH  - Models, Animal
MH  - Organ Size/drug effects
MH  - Organoselenium Compounds/*chemistry/*pharmacology
MH  - Protective Agents/*pharmacology
MH  - Rats, Sprague-Dawley
MH  - Seminal Vesicles/drug effects/pathology
MH  - Sperm Count
MH  - Sperm Motility
MH  - Spermatozoa/drug effects/pathology
MH  - Testis/drug effects/pathology/ultrastructure
MH  - *Toxicity Tests
OTO - NOTNLM
OT  - Ebselen
OT  - Manganese
OT  - Rat
OT  - Seminal vesicle
OT  - Testis
OT  - Toxicity
EDAT- 2018/04/01 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/04/01 06:00
PHST- 2017/11/19 00:00 [received]
PHST- 2018/03/14 00:00 [revised]
PHST- 2018/03/14 00:00 [accepted]
PHST- 2018/04/01 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/04/01 06:00 [entrez]
AID - S0753-3322(17)36212-1 [pii]
AID - 10.1016/j.biopha.2018.03.086 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Jun;102:739-748. doi: 10.1016/j.biopha.2018.03.086. 
      Epub 2018 Apr 5.