PMID- 29604614
OWN - NLM
STAT- MEDLINE
DCOM- 20180504
LR  - 20180504
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1084
DP  - 2018 May 1
TI  - Determination of 18 veterinary antibiotics in environmental water using 
      high-performance liquid chromatography-q-orbitrap combined with on-line 
      solid-phase extraction.
PG  - 158-165
LID - S1570-0232(17)32172-4 [pii]
LID - 10.1016/j.jchromb.2018.03.038 [doi]
AB  - The use of antibiotics and their occurrence in the environment have received 
      significant attention in recent years owing to the generation of 
      antibiotic-resistant bacteria. Antibiotic residues in water near livestock 
      farming areas should be monitored to establish effective strategies for reducing 
      the use of veterinary antibiotics. However, environmental water contamination 
      resulting from veterinary antibiotics has not been studied extensively. In this 
      work, we developed an analytical method for the simultaneous determination of 
      multiple classes of veterinary antibiotic residues in environmental water using 
      on-line solid-phase extraction (SPE)-high performance liquid chromatography 
      (HPLC)-high resolution mass spectrometry (HRMS). Eighteen popular antibiotics 
      (eight classes) were selected as target analytes based on veterinary antibiotics 
      sales in South Korea in 2015. The developed method was validated by 
      calibration-curve linearities, precisions, relative recoveries, and method 
      detection limits (MDLs)/limits of quantification (LOQs) of the selected 
      antibiotics, and applied to the analysis of environmental water samples 
      (groundwater, river water, and wastewater-treatment-plant effluent). All 
      calibration curves exhibited r(2) > 0.995 with MDLs ranging from 0.2 to 
      11.9 ng/L. Relative recoveries were between 50 and 150% with coefficients of 
      variation below 20% for all analytes (spiked at 500 ng/L) in groundwater and 
      river water samples. Relative standard deviations (RSDs) of standard-spiked 
      samples were lower than 7% for all antibiotics. The on-line SPE system eliminates 
      human-based SPE errors and affords excellent method reproducibility. Amoxicillin, 
      ampicillin, clopidol, fenbendazole, flumequine, lincomycin, sulfadiazine, and 
      trimethoprim were detected in environmental water samples in concentrations 
      ranging from 1.26 to 127.49 ng/L. The developed method is a reliable analytical 
      technique for the potential routine monitoring of veterinary antibiotics.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Kim, Chansik
AU  - Kim C
AD  - Department of Water Environment Research, National Institute of Environmental 
      Research, Hwangyeong-ro 42, Seo-gu, Incheon 22689, South Korea.
FAU - Ryu, Hong-Duck
AU  - Ryu HD
AD  - Department of Water Environment Research, National Institute of Environmental 
      Research, Hwangyeong-ro 42, Seo-gu, Incheon 22689, South Korea.
FAU - Chung, Eu Gene
AU  - Chung EG
AD  - Department of Water Environment Research, National Institute of Environmental 
      Research, Hwangyeong-ro 42, Seo-gu, Incheon 22689, South Korea. Electronic 
      address: egchung@korea.kr.
FAU - Kim, Yongseok
AU  - Kim Y
AD  - Department of Water Environment Research, National Institute of Environmental 
      Research, Hwangyeong-ro 42, Seo-gu, Incheon 22689, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20180327
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Sewage)
RN  - 0 (Veterinary Drugs)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Anti-Bacterial Agents/*analysis/chemistry/isolation & purification
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Groundwater/chemistry
MH  - Limit of Detection
MH  - Linear Models
MH  - Mass Spectrometry/methods
MH  - Reproducibility of Results
MH  - Rivers/chemistry
MH  - Sewage/chemistry
MH  - Solid Phase Extraction/*methods
MH  - Veterinary Drugs/*analysis/chemistry/isolation & purification
MH  - Water Pollutants, Chemical/*analysis/chemistry/isolation & purification
OTO - NOTNLM
OT  - Aqueous samples
OT  - HRMS
OT  - Multi-class method
OT  - On-line SPE
OT  - UHPLC
OT  - Veterinary antibiotics
EDAT- 2018/04/01 06:00
MHDA- 2018/05/05 06:00
CRDT- 2018/04/01 06:00
PHST- 2017/12/26 00:00 [received]
PHST- 2018/03/21 00:00 [revised]
PHST- 2018/03/24 00:00 [accepted]
PHST- 2018/04/01 06:00 [pubmed]
PHST- 2018/05/05 06:00 [medline]
PHST- 2018/04/01 06:00 [entrez]
AID - S1570-0232(17)32172-4 [pii]
AID - 10.1016/j.jchromb.2018.03.038 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 1;1084:158-165. doi: 
      10.1016/j.jchromb.2018.03.038. Epub 2018 Mar 27.