PMID- 2960473
OWN - NLM
STAT- MEDLINE
DCOM- 19871228
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 76
IP  - 6
DP  - 1987 Dec
TI  - Double-blind crossover comparison of enoximone and placebo in patients with 
      congestive heart failure.
PG  - 1307-11
AB  - The efficacy of oral enoximone, a new positive inotropic and vasodilator agent, 
      was assessed in 12 patients with chronic congestive heart failure (New York Heart 
      Association [NYHA] class II or III) in a double-blind randomized crossover 
      comparison with placebo. Duration of each treatment was 6 weeks and the dose of 
      enoximone was 150 mg tid. Efficacy was assessed by exercise tolerance, symptoms, 
      radionuclide angiography for ejection fraction at rest and during exercise, and 
      Holter monitoring. Two patients were withdrawn before completion of the study, 
      one with pulmonary edema after 1 week on placebo and the other for noncompliance 
      with enoximone therapy. Symptom-limited exercise capacity improved with enoximone 
      by 30% and 43% (p less than .01) compared with baseline after 2 and 6 weeks 
      treatment, respectively. Ejection fraction improved at rest (p less than .02) 
      with enoximone but not with placebo. No change was found during exercise. Heart 
      rate and blood pressure remained unaltered. During treatment with enoximone 
      symptoms of exertional dyspnea and fatigue were improved and NYHA class decreased 
      by at least one class for every patient. Holter monitoring revealed an overall 
      increase (NS) in ectopic activity during enoximone therapy. There were no serious 
      adverse effects and laboratory values did not change significantly. The addition 
      of enoximone to the existing therapy of patients with moderately severe 
      congestive heart failure provided clear and sustained subjective and objective 
      benefit when compared with placebo.
FAU - Choraria, S K
AU  - Choraria SK
AD  - Department of Cardiology, Walsgrave Hospital, Coventry, England.
FAU - Taylor, D
AU  - Taylor D
FAU - Pilcher, J
AU  - Pilcher J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Imidazoles)
RN  - 0 (Placebos)
RN  - C7Z4ITI7L7 (Enoximone)
SB  - IM
MH  - Aged
MH  - Cardiotonic Agents/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Enoximone
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Hemodynamics
MH  - Humans
MH  - Imidazoles/administration & dosage/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Placebos
MH  - Random Allocation
MH  - Time Factors
EDAT- 1987/12/01 00:00
MHDA- 1987/12/01 00:01
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 1987/12/01 00:01 [medline]
PHST- 1987/12/01 00:00 [entrez]
AID - 10.1161/01.cir.76.6.1307 [doi]
PST - ppublish
SO  - Circulation. 1987 Dec;76(6):1307-11. doi: 10.1161/01.cir.76.6.1307.